MK3281
MK3281 (Compound 33) is a non-nucleoside hepatitis C virus (HCV) NS5B polymerase inhibitor, with an EC50 of 28 nM for gt1a.
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- CAS. Nr.: 886041-60-7
- Formel: C29H37N3O3
- Molecular Weight:475.62
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | EC50 |
110 nM
Compound: 33, MK-3281
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Antiviral activity against HCV1b infected in human Huh-7 cells assessed as inhibition of viral RNA replication after 96 hrs by ELISA assay in presence of 50% normal human serum
Antiviral activity against HCV1b infected in human Huh-7 cells assessed as inhibition of viral RNA replication after 96 hrs by ELISA assay in presence of 50% normal human serum
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[PMID: 21141896] |
| Huh-7 | EC50 |
38 nM
Compound: 33, MK-3281
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Antiviral activity against HCV1b infected in human Huh-7 cells assessed as inhibition of viral RNA replication after 96 hrs by ELISA assay in presence of 10% fetal calf serum
Antiviral activity against HCV1b infected in human Huh-7 cells assessed as inhibition of viral RNA replication after 96 hrs by ELISA assay in presence of 10% fetal calf serum
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[PMID: 21141896] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 886041-60-7
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Molecular Weight 475.62
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Formel C29H37N3O3
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SMILES
CN(C)CCN([C@@H]1CN2C(C3=CC=CC=C3OC1)=C(C4CCCCC4)C5=CC=C(C(O)=O)C=C52)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Narjes F, et al. Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase. J Med Chem. 2011 Jan 13;54(1):289-301. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
MK3281 Related Classifications
HY-111204 Related Classifications
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