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Art. -Nr.: HY-105400

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NIP 502

NIP 502 is a pyridazinone derivative with orally active anti-inflammation and anti-immunology effects. NIP 502 can be used for the research of asthma.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 108616-42-8
Formel: C₁₄H₁₆ClN₃O₃
Molecular Weight:309.75

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

NIP 502 Chemical Structure

CAS. Nr.: 108616-42-8

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

NIP 502 is a pyridazinone derivative with orally active anti-inflammation and anti-immunology effects. NIP 502 can be used for the research of asthma^[1].

In Vitro

NIP 502 (30-300 μM, 5 mins) significantly inhibits FMLP (HY-P0224)-induced superoxide anion production by guinea pig alveolar macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NIP-502 (3-10 mg/kg, p.o., 1 h before antigen challenge) inhibits the antigen-induced immediate asthmatic response in passively sensitized guinea pigs^[1].
NIP-502 (30 mg/kg, p.o., 1 h before each ovalbumin aerosol inhalation) inhibits the Ovalbumin (HY-W250978)-induced increase in the number of macrophages, eosinophils, and neutrophils in the bronchoalveolar lavage fluid of guinea pigs^[1].
NIP-502 (30-50 mg/kg, p.o., 1 h before antigen challenge) inhibits the passive cutaneous anaphylactic reaction in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 108616-42-8
Molecular Weight 309.75
Formel C₁₄H₁₆ClN₃O₃
SMILES

CCOC1=C(C=CC(CNC2=C(C(NN=C2)=O)Cl)=C1)OC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yamamoto A, et al. Effects of NIP-502 on antigen-induced bronchial responses and allergic reactions in animal models. Jpn J Pharmacol. 1995 May;68(1):47-55. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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