Brophenexin
Based on 3 publication(s) in Google Scholar
Brophenexin (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin shows neuroprotective activity. Brophenexin prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. Brophenexin protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss.
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- Reinheit: 98.74%
- CAS. Nr.: 2243506-33-2
- Formel: C11H19BrCl2N2
- Molecular Weight:330.09
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Speicherung:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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HY-17551
NMDA
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HY-139426
ML-SI3
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HY-75161
(-)-Menthol
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HY-100973A
Adenosine 5′-diphosphoribose sodium
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HY-B0151S2
Pregnenolone-d4-1
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HY-107535
AS1269574
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HY-75161R
(-)-Menthol (Standard)
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HY-122051
AC1903
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HY-B0285B
Amiloride hydrochloride dihydrate
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HY-108461
TRPM8-IN-1
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HY-121539
Supercinnamaldehyde
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HY-100973AR
Adenosine 5′-diphosphoribose sodium (Standard)
Publications Citing Use of MedChemExpress (MCE) Brophenexin
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Biologische Aktivität
NMDAR/TRPM4-IN-2 (compound 8) (0-10 μM) reduces the interactions of GluN2A and GluN2B with TRPM4 in a dose-dependent manner[1].
NMDAR/TRPM4-IN-2 eliminates the CREB shutoff pathway and restores ERK1/2 activation and IEG induction while sparing the synaptic activity-driven, transcription-promoting activities of NMDARs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2243506-33-2
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Appearance Solid
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Molecular Weight 330.09
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Formel C11H19BrCl2N2
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Color White to yellow
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SMILES
NCCN(CC1=CC=CC(Br)=C1)CC.[H]Cl.[H]Cl
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Synonyms
NMDAR/TRPM4-IN-2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (3)
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Journal Impact Factor
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Most Recent
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Pharmacol Res Perspect
NMDA Receptor-Mediated Ca2+ Flux Attenuated by the NMDA Receptor/TRPM4 Interface Inhibitor Brophenexin. [Abstract]2024 Dec;12(6):e70038. PMID: 39574295 -
Lösungsmittel & Löslichkeit
DMSO : 250 mg/mL (757.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (302.95 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (6.30 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (6.30 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.0295 mL | 15.1474 mL | 30.2948 mL | 75.7369 mL |
| 5 mM | 0.6059 mL | 3.0295 mL | 6.0590 mL | 15.1474 mL | |
| 10 mM | 0.3029 mL | 1.5147 mL | 3.0295 mL | 7.5737 mL | |
| 15 mM | 0.2020 mL | 1.0098 mL | 2.0197 mL | 5.0491 mL | |
| 20 mM | 0.1515 mL | 0.7574 mL | 1.5147 mL | 3.7868 mL | |
| 25 mM | 0.1212 mL | 0.6059 mL | 1.2118 mL | 3.0295 mL | |
| 30 mM | 0.1010 mL | 0.5049 mL | 1.0098 mL | 2.5246 mL | |
| 40 mM | 0.0757 mL | 0.3787 mL | 0.7574 mL | 1.8934 mL | |
| 50 mM | 0.0606 mL | 0.3029 mL | 0.6059 mL | 1.5147 mL | |
| 60 mM | 0.0505 mL | 0.2525 mL | 0.5049 mL | 1.2623 mL | |
| 80 mM | 0.0379 mL | 0.1893 mL | 0.3787 mL | 0.9467 mL | |
| 100 mM | 0.0303 mL | 0.1515 mL | 0.3029 mL | 0.7574 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Brophenexin Related Classifications
HY-139192 Related Classifications
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