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Art. -Nr.: HY-149036

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PAA5

PAA5 is a methide carbon-centered polynuclear Au(I) cluster. PAA5 can release Au(I) causing Pro-oxidant response and accelerated ferroptosis. PAA5 increases the expression of pH2AX in a time-dependent manner. PAA5 has anticancer activity.

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Formel: C₁₄H₈Au₅B₂F₈N^2-
Molecular Weight:1348.66

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

PAA5 Chemical Structure

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

In Vitro

PAA5 (0-4 μM; 24 h) induces ferroptosis and increase of the ferroptosis marker gene prostaglandin-endoperoxide synthase 2 (PTGS2). PAA5 decreases cell viability in EJ cells with IC₅₀ values of 1.0 μM and 2.7 μM for EJ and HUVEC cells, respectively^[1].
PAA5 (1.5 μM; 4 h; EJ and HUVEC cells) releases active Au(I) metabolites within cells and increases GSH and ROS level^[1].
PAA5 (4 μM; 1, 3 and 6 h, EJ cells) causes significant DNA damage as indicated by the increase of histone H2AX phosphorylation (pH2AX)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HUVEC, EJ cells
Concentration:

0, 0.5, 1, 1.5, 2, and 4 µM
Incubation Time:

24 hours
Result:

Decreased cell viability of EJ cells 57 and 55%, respectively, compare with HUVEC cells.

Western Blot Analysis^[1]

Cell Line:

EJ cells
Concentration:

4 µM
Incubation Time:

1, 3, and 6 hours
Result:

Increased the expression of pH2AX in a time dependent manner.

In Vivo

PAA5 (1.5 μM, 100 μL; intravesical delivered into the bladder; 5 times every other day for 8 days) shows anti-tumor activity in mouse^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

4-6 weeks, 18 g, female BALB/c nude mice^[1]
Dosage:

1.5 µM, 100 µL
Administration:

Intravesical delivered into the bladder; 5 times every other day for 8 days
Result:

Exhibited a good antitumor effect with the small average tumor volume of 564 ± 180 mm³ after 22 days and no significant body weight loss.

Chemical Information

Molecular Weight 1348.66
Formel C₁₄H₈Au₅B₂F₈N^2-
SMILES

[F-][B+3]([F-])([F-])[F-].[F-][B+3]([F-])([F-])[F-].C1(C(C234[Au@@]56[Au@]27[Au]358[Au]46)=[N]([Au]78)C9=C%10C=CC=C9)=C%10C=CC=C1.[2+]
Structure Classification
- Others
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Xiao K, et, al. Pro-oxidant response and accelerated ferroptosis caused by synergetic Au(I) release in hypercarbon-centered gold(I) cluster prodrugs. Nat Commun. 2022 Aug 9;13(1):4669. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
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PAA5

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

PAA5 Related Classifications

HY-149036 Related Classifications