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Art. -Nr.: HY-150723

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PBI-6DNJ

PBI-6DNJ is an orally active and potent multivalent glycosidase inhibitor. PBI-6DNJ exhibits good inhibition activity against α-glucosidase from mice, with a K_i of 0.14 μM. PBI-6DNJ exhibits good hypoglycemic activity. PBI-6DNJ can be used for type 2 diabetes research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2857098-72-5
Formel: C₁₂₀H₁₄₆N₂₆O₃₆
Molecular Weight:2528.60

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (281 KB)

PBI-6DNJ Chemical Structure

CAS. Nr.: 2857098-72-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Ki: 0.02 ± 0.002 μM (α-glucosidase from rice), 0.08 ± 0.03 μM (α-mannosidase from jack bean), 0.14 ± 0.007 μM (α-glucosidase from mice), 18.88 ± 0.30 μM (α-glucosidase from aspergilcus niger)^[1]

In Vivo

PBI-6DNJ (0-2 mg/kg, Orally, once) reduces postprandial blood glucose (PBG) levels^[1].
PBI-6DNJ (2.0 mg/kg, Orally, daily for 7 day) has good biocompatibility and no damage to mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL-6J mice (twenty-eight, 4-5 weeks old, 18-20 g)^[1]
Dosage:

0.5, 1.0 and 2.0 mg/kg
Administration:

Orally, once
Result:

Reduced postprandial blood glucose (PBG) level, resulting in 24.41 ± 3.02%, 34.65 ± 9.66%, and 37.77 ± 4.35% of decreases in PBG levels at the doses of 0.5, 1.0 and 2.0 mg/kg, respectively.

Animal Model:

C57BL-6J mice (twenty-eight, 4-5 weeks old, 18-20 g)^[1]
Dosage:

2.0 mg/kg
Administration:

Orally, daily for 7 day
Result:

Resulted in increase of the level of UREA (8.63 ± 0.59 mmol/L) and decrease of the level of UA level (242.06 ± 14.77 μmol/L). No obvious differences in the levels of UREA and UA were observed. Showed a slight decrease of 0.30 mmol/L in the level of LDL. The AST level of PBI-6DNJ group (269.71 ± 39.77 U/L) was higher than that of the control group (221.38 ± 23.03 U/L), and the ALT level (59.14 ± 7.13 U/L) was lower than that of the control group (70.49 ± 8.78U/L).

Chemical Information

CAS. Nr. 2857098-72-5
Molecular Weight 2528.60
Formel C₁₂₀H₁₄₆N₂₆O₃₆
SMILES

OC[C@H]1[C@@H]([C@H]([C@@H](CN1CCCN2C=C(COC3=CC=C(C=C3)OC4=CC(C(N5CC6=CN(CCCN7[C@@H](CO)[C@@H]([C@H]([C@@H](C7)O)O)O)N=N6)=O)=C8C9=C4C%10=C%11C(C(C%12=O)=CC(OC%13=CC=C(C=C%13)OCC%14=CN(CCCN%15[C@H](CO)[C@H]([C@@H]([C@H](C%15)O)O)O)N=N%14)=C%11C9=C(C=C8C5=O)OC%16=CC=C(C=C%16)OCC%17=CN(CCCN(C[C@H]([C@@H]([C@H]%18O)O)O)[C@H]%18CO)N=N%17)=C(C=C%10OC%19=CC=C(OCC%20=CN(CCCN%21[C@H](CO)[C@H]([C@@H]([C@H](C%21)O)O)O)N=N%20)C=C%19)C(N%12CC%22=CN(CCCN%23[C@H](CO)[C@H]([C@@H]([C@H](C%23)O)O)O)N=N%22)=O)N=N2)O)O)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Signal Pathway Related

Research Protocol for Metabolic Diseases
AMP-activated protein kinase, AMPK, is a conserved cellular energy sensor that responds to reduced cellular energy status and coordinates metabolism by increasing ATP-generating catabolic pathways while suppressing ATP-consuming anabolic processes. In metabolic disease research, the AMPK pathway is experimentally relevant because it regulates hepatic lipid synthesis, fatty acid oxidation, glucose production, skeletal-muscle glucose disposal, mTORC1-linked biosynthesis, autophagy, mitochondrial homeostasis, and whole-body energy balance. The central pathway logic is that energy stress, metformin, exercise-like stimulation, or direct AMPK activators increase AMPKα Thr172 phosphorylation and downstream substrate phosphorylation, including ACC and RAPTOR. Phosphorylation of ACC suppresses lipogenesis and supports fatty acid oxidation, whereas phosphorylation of RAPTOR suppresses mTORC1 signaling and links cellular energy status to growth and protein synthesis control. The pathway is linked

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Jian-XingYang, et al. Multivalent glucosidase inhibitors based on perylene bisimide and iminosugar conjugates. European Journal of Medicinal Chemistry. 2022 November 5, 241(3):114621. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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