Plumieride
Plumieride is an antifungal agent. Plumieride has strong fungitoxicity against some dermatophytes. Plumieride has little cytotoxic activity against the P388 leukaemia cell line with an IC50 of 85 μg/mL.
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- CAS. Nr.: 511-89-7
- Formel: C21H26O12
- Molecular Weight:470.42
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Cancer cell lines | ED50 |
>50 μg/mL
Compound: 8
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Cytotoxicity against human breast cancer cells
Cytotoxicity against human breast cancer cells
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[PMID: 1965200] |
| Cancer cell lines | ED50 |
>50 μg/mL
Compound: 8
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Cytotoxicity against human colon cancer cells
Cytotoxicity against human colon cancer cells
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[PMID: 1965200] |
| Cancer cell lines | ED50 |
>50 μg/mL
Compound: 8
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Cytotoxicity against human lung cancer cells
Cytotoxicity against human lung cancer cells
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[PMID: 1965200] |
| HT-1080 | ED50 |
>50 μg/mL
Compound: 8
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Cytotoxicity against human HT1080 cells
Cytotoxicity against human HT1080 cells
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[PMID: 1965200] |
| KB | ED50 |
>50 μg/mL
Compound: 8
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Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
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[PMID: 1965200] |
| Melanoma cell | ED50 |
>50 μg/mL
Compound: 8
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Cytotoxicity against human melanoma cells
Cytotoxicity against human melanoma cells
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[PMID: 1965200] |
| P388 | ED50 |
>50 μg/mL
Compound: 8
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Cytotoxicity against mouse P388 cells
Cytotoxicity against mouse P388 cells
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[PMID: 1965200] |
Chemical Information
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CAS. Nr. 511-89-7
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Molecular Weight 470.42
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Formel C21H26O12
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SMILES
OC[C@H]([C@@H](O)[C@H](O)[C@H]1O)O[C@@]1([H])O[C@H]2[C@]3([H])[C@@](O4)(C=C[C@]3([H])C(C(OC)=O)=CO2)C=C([C@@H](O)C)C4=O
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Synonyms
Agoniadin; NSC 609065
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Plumieride Related Classifications
HY-N3041 Related Classifications
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