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Art. -Nr.: HY-123280

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SCH 54388

SCH 54388 is an orally active metabolite of Felbamate (HY-B0184). SCH 54388 significantly attenuates the functional impairment effects induced by Scopolamine (HY-N0296) or Dizocilpine (HY-15084B). SCH 54388 can be used in research related to cognitive impairment.

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CAS. Nr.: 25451-53-0
Formel: C₁₀H₁₃NO₃
Molecular Weight:195.22

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

SCH 54388 Chemical Structure

CAS. Nr.: 25451-53-0

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Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vivo

SCH 54388 (0.1-10 mg/kg; s.c. or p.o.; single administration) reverses scopolamine-induced cognitive impairment in BALB mice^[1].
SCH 54388 (0.01-0.1 mg/kg; s.c.; single administration) reverses dizocilpine-induced cognitive impairment in CF-1 mice^[1].
SCH 54388 (10-100 mg/kg; s.c.; single administration) produces statistically significant analgesic effects in CF-1 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Charles River BALB (male, 25-30 g, scopolamine-induced cognitive impairment)^[1]
Dosage:

0.1 mg/kg; 1.0 mg/kg; 10 mg/kg
Administration:

s.c.; single dose
Result:

Produced mean reentry latencies statistically greater than scopolamine alone.
Demonstrated a statistically significant overall treatment effect.

Animal Model:

Charles River BALB (male, 25-30 g, scopolamine-induced cognitive impairment)^[1]
Dosage:

0.1 mg/kg; 1.0 mg/kg; 10 mg/kg
Administration:

p.o.; single dose
Result:

Produced mean reentry latencies statistically greater than scopolamine alone.
Demonstrated a statistically significant overall treatment effect.

Animal Model:

Charles River CF-1 (male, 25-30 g, dizocilpine-induced cognitive impairment)^[1]
Dosage:

0.01 mg/kg; 0.1 mg/kg
Administration:

s.c.; single dose
Result:

Produced mean reentry latencies statistically greater than dizocilpine alone.
Demonstrated a statistically significant overall treatment effect.

Animal Model:

Charles River CF-1 (male, 25-30 g)^[1]
Dosage:

10 mg/kg; 100 mg/kg
Administration:

s.c.; single dose
Result:

Produced statistically significant increases in mean escape jump latencies compared to vehicle-treated animals.

Chemical Information

CAS. Nr. 25451-53-0
Molecular Weight 195.22
Formel C₁₀H₁₃NO₃
SMILES

O=C(N)OCC(CO)C1=CC=CC=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Smith RD, et al. Reduction of dizocilpine and scopolamine-induced deficits in avoidance responding by SCH 54388, a metabolite of felbamate. Pharmacol Biochem Behav. 1997;58(3):657-664. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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