Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2438 Results for "
decrease
" in MedChemExpress (MCE) Product Catalog:
Products (2438)
2438 Results for "decrease" in MCE Product Catalog:
Art. -Nr.: HY-W014332R
CAS. Nr.: 102-06-7
Forschungsgebiete:
1,3-Diphenylguanidine (Standard) is the analytical standard of 1,3-Diphenylguanidine (HY-W014332). This product is intended for research and analytical applications. 1,3-Diphenylguanidine is a widely used accelerator in rubber vulcanization. 1,3-Diphenylguanidine increases ROS activity and decreases SOD and CAT activity. 1,3-Diphenylguanidine accelerates the vulcanization process. 1,3-Diphenylguanidine impairs the reproduction and growth of Moina macrocopa [1] [2] [3] .
Art. -Nr.: HY-W088066
CAS. Nr.: 10101-89-0
Trisodium phosphate dodecahydrate is an Antibacterial agent. Trisodium phosphate dodecahydrate reduces the counts of Escherichia coli O157:H7 and Salmonella typhimurium attached to the surfaces of beef fat and fascia. Trisodium phosphate dodecahydrate modulates the growth parameters of Listeria monocytogenes in vitro: low concentrations shorten the lag phase and increase the maximum growth rate, while high concentrations prolong the lag phase and decrease the maximum growth rate. Trisodium phosphate dodecahydrate is used in poultry processing .
Art. -Nr.: HY-W142457
CAS. Nr.: 18479-58-8
Target:
Forschungsgebiete:
Dihydromyrcenol is an orally active flavor ingredient and Antifungal agent. Dihydromyrcenol acts as a toxicant. Dihydromyrcenol induces phototoxicity-related growth inhibition in Bakers' Yeast. In pregnant rats, Dihydromyrcenol causes threshold maternal toxicity by reducing feed consumption and body weight gain, and also induces threshold developmental toxicity by decreasing fetal body weight, inhibiting ossification of metatarsal bones in the hind paws, increasing the number of extra thoracic vertebrae ribs, and altering vertebral counts .
Art. -Nr.: HY-W248115
CAS. Nr.: 137829-79-9
Target:
Forschungsgebiete:
Pyrromethene 597 is a temperature-sensitive BODIPY-class laser fluorescent dye whose fluorescence anisotropy decreases with increasing temperature, Ex/Em =527/557 nm. Pyrromethene 597 can serve as a temperature probe in solution and as a whispering gallery mode (WGM) microlaser gain medium. Pyrromethene 597 can be doped into photoresists for in situ fabrication of microlaser devices within living cells. Pyrromethene 597 can be used in fluorescence imaging and microlaser-related research .
Art. -Nr.: HY-W713900
CAS. Nr.: 2469242-78-0
Art. -Nr.: HY-W752587
CAS. Nr.: 349553-98-6
Synonyms: (±)-Mevalonolactone-d4; Mevalolactone-d4
Art. -Nr.: HY-W759219
Synonyms: (+)-Adrenosterone-13C3; 11-Keto-androstedione-13C3
Art. -Nr.: HY-129108
CAS. Nr.: 205252-57-9
Synonyms: (9Z)-UAB-30
Forschungsgebiete:
9-cis-UAB30 is a rexinoid agonist. 9-cis-UAB30 significantly decreases the proliferation, viability, and motility of both patient-derived xenografts (PDXs). 9-cis-UAB30 induced cell-cycle arrest as demonstrated by the significant increase in the percentage of cells in G1 and a decrease in the percentage of cells in S phase by downregulating SKP2 and/or 20S proteasome activity, which leads to increased p27kip1 protein stability. 9-cis-UAB30 downregulates the abundance of stem cell marker mRNAs (Oct4, Nanog, Sox2, nestin) and upregulates the abundance of differentiation marker mRNAs (β3-tubulin, NSE, HOXC9, GAP43). 9-cis-UAB30 has no adverse effects on the central nervous system and cardiovascular system at the tested dose. 9-cis-UAB30 can be used for the study of neuroblastoma, cutaneous T-cell lymphomas, and breast cancer .
Art. -Nr.: HY-100381R
CAS. Nr.: 28643-80-3
Synonyms: BMS 068645; DWH 146e
Target:
Forschungsgebiete:
Apadenoson (BMS 068645) is a selective A2A adenosine receptor agonist and coronary vasodilator with a Ki of 0.5 nM for hA2AAR. Apadenoson induces anti-inflammatory signaling and reduces cytokine production. Apadenoson decreases weight loss in SARS-CoV-2-infected K18-hACE2 mice. Apadenoson exerts potent anti-inflammatory activity. Apadenoson can be used for research on COVID-19 and inflammatory bowel disease .
Art. -Nr.: HY-107531R
CAS. Nr.: 1384424-80-9
Target:
Forschungsgebiete:
A 1070722 (Standard) is the analytical standard of A 1070722 (HY-107531). This product is intended for research and analytical applications. A 1070722 is a potent and selective glycogen synthase Kinase 3 (GSK-3) inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. A 1070722 can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain. A 1070722 decreases spontaneous locomotion .
Art. -Nr.: HY-108634R
CAS. Nr.: 105219-56-5
Synonyms: WEB 2086 (Standard)
Forschungsgebiete:
Apafant (Standard) is the analytical standard of Apafant (HY-108634). This product is intended for research and analytical applications. Apafant (WEB 2086), a chemical probe, is a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a Ki of 9.9 nM. Apafant increases the gene expression of PAF-r, α-globin, β-globin, decreases the c-myb gene expression. Apafant shows a protective effect on alkyl-PAF-mediated lethalit .
Art. -Nr.: HY-108691R
CAS. Nr.: 1407966-77-1
Target:
Forschungsgebiete:
PF-06465469 (Standard) is the analytical standard of PF-06465469 (HY-108691). This product is intended for research and analytical applications. PF-06465469 is a covalent inhibitor of ITK with an IC50 of 2 nM. PF-06465469 also inhibits BTK. PF-06465469 inhibits cell migration in response to CXCL12. PF-06465469 decreases PD-1 and LAG-3 expression. PF-06465469 can be used to study leukemia and T-cell lymphoma .
Art. -Nr.: HY-108842
CAS. Nr.: 215647-85-1
Synonyms: PegIFN a-2b; Sch 54031; Sylatron; ViraferonPeg
Peginterferon alfa-2b (PegIFN a-2b; Sch 54031) is an immunomodulator and an agonist of IFNAR. Peginterferon alfa-2b is a recombinant alfa-2b interferon covalently linked PEG with antiviral activity against HCV. Peginterferon alfa-2b decreases viral DNA in HIV. Peginterferon alfa-2b can be used in research of melanoma and hepatitis C .
Synonyms: ZINC08010136
Target:
Forschungsgebiete:
Z62954982 (ZINC08010136) is a potent, selective and cell-permeable Rac1 (IC50=12 μM) inhibitor that is 4 times more effective than NSC23766 (HY-15723A) (IC50=50 μM). Z62954982 disrupts the Rac1/Tiam1 complex and decreases cytoplasmic levels of active Rac1 (GTP-bound Rac1), without affecting the activity of other Rho GTPases (such as Cdc42 or RhoA) .
Art. -Nr.: HY-116143
CAS. Nr.: 1352011-38-1
Target:
Forschungsgebiete:
SAR127303 is an orally active, selective, competitive monoacylglycerol lipase (MAGL) covalent inhibitor with IC50s of 3.8 nM and 29 nM for mouse and human MAGL, respectively. SAR127303 potently elevates hippocampal levels of 2-AG in mice. SAR127303 decreased long term potentiation (LTP) of CA1 synaptic transmission and acetylcholine release in the hippocampus. SAR127303 produces antinociceptive effects in assays of inflammatory and visceral pain. SAR127303 slows down epileptogenesis .
Art. -Nr.: HY-116790B
CAS. Nr.: 36507-48-9
Synonyms: (Rac)-Penbutolol; (±)-Isopenbutolol
Target:
Forschungsgebiete:
(±)-Penbutolol ((Rac)-Penbutolol) is the racemic mixture of Penbutolol. (±)-Penbutolol is an orally active β-adrenergic receptor antagonist. (±)-Penbutolol antagonizes exercise-induced tachycardia, reduces the increase in peak expiratory flow rate (PEFR) caused by exercise, and decreases resting plasma renin activity (PRA). (±)-Penbutolol reaches peak plasma concentration 1 hour after oral administration, with a half-life of 4.5 hours, and is converted into an active metabolite in the body. (±)-Penbutolol can be used in cardiovascular-related disease research .
Art. -Nr.: HY-121166
CAS. Nr.: 93221-48-8
Synonyms: (S)-Betaxolol
Target:
Forschungsgebiete:
Levobetaxolol is a potent and high affinity β-adrenergic antagonist with IC50 values of 33.2, 2970, 709 nM for guinea pig atrial β1, tracheal β2 and rat colonic β3 receptors, respectively. Levobetaxolol reduces IOP (intraocular pressure). Levobetaxolol exhibits a micromolar affinity for L-type Ca21-channels. Levobetaxolol decreases the effects of ischaemia/reperfusion injury in rats. Levobetaxolol has the potential for the research of glaucoma .
Target:
Forschungsgebiete:
OTS193320, a imidazo[1,2-a]pyridine compound, is a SUV39H2 methyltransferase activity inhibitor. OTS193320 decreases global histone H3 lysine 9 tri-methylation levels in breast cancer cells and triggers apoptotic cell death. Combination of OTS193320 with Doxorubicin (HY-15142A) results in reduction of γ-H2AX levels as well as cancer cell viability compared to a single agent OTS193320 or DOX .
Art. -Nr.: HY-124122
CAS. Nr.: 1802665-43-5
Forschungsgebiete:
BPTQ is a potent inhibitor against VEGFR1 and CHK2 with IC50 values of 0.54 and 1.70 µmol/L, respectively. BPTQ is also an intercalator of DNA with anticancer activities. BPTQ inhibits the proliferation of HL-60 cells by arresting cells at S and G2/M phase with an IC50 value of 12 µmol/L. BPTQ also activates the mitochondria-mediated Apoptosis pathway by a decrease in mitochondrial membrane potential, increase in the Bax:Bcl-2 ratio and activation of caspases .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
