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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
102 Results for "
CD-1
" in MedChemExpress (MCE) Product Catalog:
Products (102)
102 Results for "CD-1" in MCE Product Catalog:
4
4 Cited Publications
Synonyms: α-GalCer; KRN7000
Forschungsgebiete:
α-Galactosylceramide (α-GalCer) is a synthetic glycolipid with antitumorial and immunostimulatory. α-Galactosylceramide is a very potent NKT cell agonist and binds effectively to CD1d. The complex of α-Galactosylceramide plus CD1d binds the NKT cell TCR (T cell antigen receptor) [1] .
1
1 Cited Publications
Art. -Nr.: HY-P990006
CAS. Nr.: 2750005-84-4
Synonyms: TEV-48574; SAR-447189; TEV-574
Target:
Forschungsgebiete:
1
1 Cited Publications
Art. -Nr.: HY-A0277
CAS. Nr.: 94361-06-5
Target:
Forschungsgebiete:
Cyproconazole is a triazole fungicide used to protect crops, fruits and vegetables against a wide range of fungal pathogens. Cyproconazole can cause hepatocellular adenomas and carcinomas in CD-1 mice. Cyproconazole also exhibits low toxicity to zebrafish embryos and affects locomotor activity [1] .
Art. -Nr.: HY-174990
CAS. Nr.: 2927452-83-1
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Forschungsgebiete:
HW201877 is a potent and orally active 15-prostaglandin dehydrogenase (15-PGDH) inhibitor with an IC50 of 3.6 nM. HW201877 demonstrates robust cellular efficacy in elevating PGE2 levels in A549 cells and exhibits remarkable efficacy in animal models of tissue injury and fibrosis. HW201877 can be used for the study of inflammatory bowel disease (IBD), idiopathic pulmonary fibrosis (IPF) and Crohn’s disease (CD) .
Art. -Nr.: HY-W002199
CAS. Nr.: 647-42-7
Synonyms: 6:2 FTOH; 1H,1H,2H,2H-Perfluoro-1-octanol; 2-(Perfluorohexyl)ethanol
Target:
Forschungsgebiete:
6:2 Fluorotelomer alcohol (6:2 FTOH) is an orally active, blood-brain barrier-permeable modulator of cyclin D1 and ETS1. 6:2 Fluorotelomer alcohol downregulates cyclin D1 expression, upregulates ETS1 via the TNF-α/ERK 1/2 pathway, impairs mitochondrial membrane potential and respiratory function, increases reactive oxygen species levels, disrupts calcium homeostasis and activates endoplasmic reticulum stress markers, and induces cell proliferation inhibition and endothelial-mesenchymal transition. Furthermore, 6:2 Fluorotelomer alcohol induces morphological abnormalities in zebrafish embryos and liver developmental damage, while disrupting the brain immune microenvironment in mice, causing systemic toxicity and delayed pup maturation in CD-1 mice. 6:2 Fluorotelomer alcohol also induces cortical neuron apoptosis, glial cell activation, synaptic abnormalities, colonic barrier damage, intestinal dysbiosis and autism spectrum disorder-like symptoms in mice. 6:2 Fluorotelomer alcohol shows no mutagenic, clastogenic, primary skin/eye irritation or skin sensitizing effects, exhibits no selective reproductive toxicity in CD-1 mice, and is classified as GHS Category 4 for acute oral toxicity. 6:2 Fluorotelomer alcohol can be used in studies of neurodevelopmental disorders and autism spectrum disorders [1] .
Synonyms: BT-11
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Forschungsgebiete:
Omilancor (BT-11) is an orally active lanthionine synthetase cyclase-like receptor 2 (LANCL2) activator. Omilancor can be used for the study of psoriasis, inflammatory bowel disease (IBD), and Crohn's disease (CD) .
Art. -Nr.: HY-P990273
Target:
Forschungsgebiete:
Androgen receptor-IN-6 (compound 16) is an orally available androgen receptor (Androgen Receptor) potent inhibitor (IC50=0.12 μM in vitro), targeting the disordered N-terminal domain (NTD). Androgen receptor-IN-6 has good Caco2 cell membrane permeability and has an oral activity (F/%) of 16% in male CD-1 mice [1].
Art. -Nr.: HY-P1302
CAS. Nr.: 178249-41-7
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Art. -Nr.: HY-W010396
CAS. Nr.: 599-04-2
Art. -Nr.: HY-N10116A
CAS. Nr.: 483-77-2
Category:
Target:
Forschungsgebiete:
(±)-Pantothenic acid ((±)-Pantothenate), a B-vitamin, is an essential vitamin required for the biosynthesis of coenzyme A (CoA) in mammalian cells. Pantothenic acid has protective activity against valproic acid (VPA)-induced neural tube defects (NTD) in CD-1 mice [1].
Art. -Nr.: HY-162484
CAS. Nr.: 3089845-68-8
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Forschungsgebiete:
GZNL-P36 is an orally active inhibitor for SARS-CoV-2 papain-like protease (PL pro), with an IC50 of 6.45 nM. GZNL-P36 inhibits SARS-CoV and its variants with EC50 range from 58.2 nM to 2.66 μM. GZNL-P36 exhibits a peak plasma concentration Cmax of 549 ng/mL, a half-life T1/2 of 1.45 h and a bioavailability of 74.7% in CD-1 mouse. GZNL-P36 exhibits antiviral activity in SARS-CoV-2 XXB.1 infection in mouse [1].
Art. -Nr.: HY-P990287
Target:
Forschungsgebiete:
Art. -Nr.: HY-A0277R
CAS. Nr.: 94361-06-5
Target:
Forschungsgebiete:
Cyproconazole (Standard) is the analytical standard of Cyproconazole. This product is intended for research and analytical applications. Cyproconazole is a triazole fungicide used to protect crops, fruits and vegetables against a wide range of fungal pathogens. Cyproconazole can cause hepatocellular adenomas and carcinomas in CD-1 mice. Cyproconazole also exhibits low toxicity to zebrafish embryos and affects locomotor activity [1] .
Art. -Nr.: HY-B0389S20
CAS. Nr.: 201417-06-3
Synonyms: Glucose-13C,d-1; D-(+)-Glucose-13C,d-1; Dextrose-13C,d-1
Art. -Nr.: HY-P1302A
Target:
Forschungsgebiete:
Art. -Nr.: HY-175365
Target:
Forschungsgebiete:
GCS-12–6 is a potent Th2-selective NKT cell agonist targeting CD1d protein. GCS-12–6 is promising for research of autoimmune diseases (e.g., inflammatory bowel disease, multiple sclerosis) [1].
Art. -Nr.: HY-RS02200
Target:
Forschungsgebiete:
CD1B Human Pre-designed siRNA Set A contains three designed siRNAs for CD1B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS02201
Target:
Forschungsgebiete:
CD1C Human Pre-designed siRNA Set A contains three designed siRNAs for CD1C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
