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Duvakitug

(Synonyms: TEV-48574; SAR-447189; TEV-574)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Duvakitug (TEV-48574) is a humanized IgG1-λ2 monoclonal antibody targeting to TNFSF15/TL1A. Duvakitug' main expression system is CHOK1SV cells endogenously expressing glutamine synthetase (GS). Duvakitug can be used in the study of Crohn's Disease (CD).

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  • Reinheit: 99.76%
  • CAS. Nr.: 2750005-84-4
  • Molecular Weight:143.64 kDa
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Duvakitug
  • Experimental Validation Results for Duvakitug
  • Experimental Validation Results for Duvakitug
  • Experimental Validation Results for Duvakitug
  • Duvakitug Chemical Structure
    Duvakitug Chemical Structure
CAS. Nr.: 2750005-84-4
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[email protected] [email protected]
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Assay Types
  • 1/16

    Human IgG1 lambda

  • 1/16

    Immobilized TL1A/TNFSF15 Protein, Human can bind Duvakitug. The EC50 for this effect is 31.43 ng/mL.

  • 1/16

    Loaded TL1A/TNFSF15 Protein, Human (161a.a, HEK293, His, HY-P78447A) on AHC2 biosensor, can bind Duvakitug with an affinity constant of 4.777E-10 M as determined in BLI assay.

  • 1/16

    Flow cytometric analysis of 1×106 MCF-7 cells labelling TL1A (red) with Duvakitug (HY-P990006). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 lambda2 Isotype Control (HY-P990096, blue) was used as the isotype control.

  • Duvakitug Chemical Structure
    1/16
  • Duvakitug
  • Immobilized TL1A/TNFSF15 Protein, Human can bind Duvakitug. The EC50 for this effect is 31.43 ng/mL.
  • Loaded TL1A/TNFSF15 Protein, Human (161a.a, HEK293, His, HY-P78447A) on AHC2 biosensor, can bind Duvakitug with an affinity constant of 4.777E-10 M as determined in BLI assay.
  • Flow cytometric analysis of 1×106 MCF-7 cells labelling TL1A (red) with Duvakitug (HY-P990006). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 lambda2 Isotype Control (HY-P990096, blue) was used as the isotype control.