Topixantrone
Topixantrone (BBR 3576) is an antitumor agent, and shows antitumor activity on prostate carcinoma.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 156090-18-5
- Formel: C21H26N6O2
- Molecular Weight:394.47
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LoVo | IC50 |
0.3 μg/mL
Compound: 13x
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In vitro cytotoxicity on human colon adenocarcinoma (LoVo ) tumor cell line.
In vitro cytotoxicity on human colon adenocarcinoma (LoVo ) tumor cell line.
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[PMID: 9876113] |
| LoVo | IC50 |
57 μg/mL
Compound: 13x
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In vitro cytotoxicity on human colon adenocarcinoma resistant to doxorubicin (LoVo/Dx ) tumor cell line.
In vitro cytotoxicity on human colon adenocarcinoma resistant to doxorubicin (LoVo/Dx ) tumor cell line.
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[PMID: 9876113] |
Chemical Information
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CAS. Nr. 156090-18-5
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Molecular Weight 394.47
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Formel C21H26N6O2
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SMILES
O=C1C2=C(C3=NN(CCNCCO)C4=CC=C(C1=C34)NCCN(C)C)C=NC=C2
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Synonyms
BBR 3576
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Topixantrone Related Classifications
HY-105164 Related Classifications
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