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Art. -Nr.: HY-W075176

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Transfluthrin

Transfluthrin is an insecticide with extremely low acute toxicity to vertebrates. Transfluthrin acts as a mosquito repellent, exerts mosquito control effects via electric heating fumigators, and is widely used in studies related to malaria, bancroftian filariasis and mosquito-borne infectious diseases. Transfluthrin may also induce adverse reactions such as pulmonary sensory irritation, sensitization, genotoxicity and respiratory depression, and can increase the concentrations and activities of CYP2E1 and CYP3A2 in rat brains. Transfluthrin can be removed from wastewater through biodegradation and activated sludge adsorption, and can be degraded by microorganisms such as Azovibrio and Tauera.

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CAS. Nr.: 118712-89-3
Formel: C₁₅H₁₂Cl₂F₄O₂
Molecular Weight:371.15

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Transfluthrin Chemical Structure

CAS. Nr.: 118712-89-3

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Beschreibung

In Vitro

Transfluthrin (0.015-5 mg per plate; 60 min/20 min pre-incubation, 48-72 h plate incubation) is non-genotoxic in bacterial reverse mutation assays for reference transfluthrin (TFL-R), while two generic transfluthrin samples (TFL-GVI, TFL-GVIII) induce dose-dependent base-pair substitutions in Salmonella typhimurium TA100 without metabolic activation^[1].
Transfluthrin is genotoxic to human nasal mucosal epithelial cells of the inferior and middle nasal conchae^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Transfluthrin (10×10⁶ normal usage rate; inhalation; repeated; 2 weeks) causes no measurable toxic effects in rats, classifying the products as hazard class 4^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

White outbred male (220-250 g)^[3]
Dosage:

10x normal usage rate
Administration:

Inhalation; repeated; 2 weeks
Result:

Detected no changes in nervous system, respiratory system, or liver function parameters.
Classified products as hazard class 4.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 118712-89-3
Molecular Weight 371.15
Formel C₁₅H₁₂Cl₂F₄O₂
SMILES

O=C(OCC1=C(C(F)=CC(F)=C1F)F)[C@H]2C(C)([C@@H]2/C=C(Cl)\Cl)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Pauluhn J, Ozaki K. Transfluthrin: Comparative efficacy and toxicity of reference and generic versions[J]. Regulatory Toxicology and Pharmacology, 2015, 71(1): 78-92.

[2]. Pates H V, et al. Personal protection against mosquitoes in Dar es Salaam, Tanzania, by using a kerosene oil lamp to vaporize transfluthrin[J]. Medical and Veterinary Entomology, 2002, 16(3): 277-284.

[3]. Прохоров Н И, Ходыкина Т М, Виноградова А И, et al. Оценка безопасности бытовых инсектицидных электрофумигирующих средств на основе трансфлутрина и праллетрина[J]. Гигиена и санитария, 2019, 98(4): 374-379.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Transfluthrin

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Transfluthrin Related Classifications

HY-W075176 Related Classifications