(E)-Cynarin
(E)-Cynarin ((E)-Cynarine) is the E-isomer of Cynarin (HY-N0359). Cynarin is an anti-asphyxiant with multiple biological activities, possessing antioxidant, antihistamine, and antiviral activities, etc.
For research use only. We do not sell to patients.
- CAS No.: 212891-05-9
- Formula: C25H24O12
- Molecular Weight:516.45
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MT2 | ED50 |
4 μM
Compound: 1,5-DCQA
|
Concentration that inhibits Human Immunodeficiency Virus Type 1 (HIV-1)-induced death of MT-2 cells
Concentration that inhibits Human Immunodeficiency Virus Type 1 (HIV-1)-induced death of MT-2 cells
|
[PMID: 9986720] |
Chemical Information
-
CAS No. 212891-05-9
-
Molecular Weight 516.45
-
Formula C25H24O12
-
SMILES
OC(C=C1/C=C/C(O[C@]2(C[C@H]([C@H]([C@@H](C2)O)O)OC(/C=C/C3=CC(O)=C(C=C3)O)=O)C(O)=O)=O)=C(C=C1)O
-
Synonyms
(E)-Cynarine; (E)-Plemocil
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
References
[1]. Topal M, et al. Antioxidant, antiradical, and anticholinergic properties of cynarin purified from the Illyrian thistle (Onopordum illyricum L.). J Enzyme Inhib Med Chem. 2016;31(2):266-75. [Content Brief]
[2]. Dong GC, et al. Blocking effect of an immuno-suppressive agent, cynarin, on CD28 of T-cell receptor. Pharm Res. 2009 Feb;26(2):375-81. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(E)-Cynarin Related Classifications
HY-N0359A Related Classifications
Powered by Bioz