KLK8 - kallikrein related peptidase 8 Gene

Also Known as NP; HNP; NRPN; PRSS19; TADG14

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11202

About KLK8

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:50,996,008-51,001,604 (from NCBI)

This gene has 12 transcripts (splice variants), 108 orthologues and 12 paralogues. Biased expression in skin (RPKM 32.0) and esophagus (RPKM 29.8).

Summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel Cancer and Other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian Cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

KLK8 Products (5)

mRNA Protein Name
NM_001281431.2 NP_001268360.1 kallikrein-8 isoform 5
NM_007196.4 NP_009127.1 kallikrein-8 isoform 1 preproprotein
NM_144505.3 NP_653088.1 kallikrein-8 isoform 2 precursor
NM_144506.3 NP_653089.1 kallikrein-8 isoform 3 precursor
NM_144507.3 NP_653090.1 kallikrein-8 isoform 4

KLK8 Protein Structure

Trypsin

Trypsin: Trypsin (34 - 252)

  • 0
  • 100
  • 200
  • 260 a.a.
Protein Preferred Names Protein Names

kallikrein-8

  • ovasin

KLK8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KLK8 O60259 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
KLK8 O60259 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
Intra
KLK8 O60259 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
KLK8 O60259 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
KLK8 O60259 KRT34 Homo sapiens O76011
Validated Y2H
32296183
Intra
KLK8 O60259 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
KLK8 O60259 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
KLK8 O60259 KRTAP1-1 Homo sapiens Q07627
Validated Y2H
32296183
Intra
KLK8 O60259 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
KLK8 O60259 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
KLK8 O60259 NOTCH2NLC Homo sapiens P0DPK4
Validated Y2H
32296183
Intra
KLK8 O60259 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
KLK8 O60259 KLK6 Homo sapiens Q92876
Y2H Pooling
32814053
Intra
KLK8 O60259 KLK6 Homo sapiens Q92876
Validated Y2H
32814053
Intra
KLK8 O60259 KLK6 Homo sapiens Q92876
Y2H Array
32814053
Intra
KLK8 O60259 TGFBR2 Homo sapiens P37173
Validated Y2H
32814053
Intra
KLK8 O60259 TGFBR2 Homo sapiens P37173
Y2H Pooling
32814053
Intra
KLK8 O60259 TGFBR2 Homo sapiens P37173
Y2H Array
32814053
Intra
KLK8 O60259 SERPINH1 Homo sapiens P50454
Y2H Pooling
32814053
Intra
KLK8 O60259 SERPINH1 Homo sapiens P50454
Validated Y2H
32814053
Intra
KLK8 O60259 SERPINH1 Homo sapiens P50454
Y2H Array
32814053
Intra
KLK8 O60259 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
KLK8 O60259 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
KLK8 O60259 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra
KLK8 O60259 KRTAP5-9 Homo sapiens P26371
Validated Y2H
32296183
Intra
KLK8 O60259 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra
KLK8 O60259 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
KLK8 O60259 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
KLK8 O60259 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
KLK8 O60259 ZDHHC17 Homo sapiens Q8IUH5
Y2H Array
24705354
Intra
KLK8 O60259 ZDHHC17 Homo sapiens Q8IUH5
Lumier
24705354
Intra
KLK8 O60259 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Intra
KLK8 O60259 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Intra
KLK8 O60259 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Intra
KLK8 O60259 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
KLK8 O60259 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
KLK8 O60259 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KLK8 Proteins

Cat. No. Product Name Accession Purity
HY-P73265 Kallikrein-8 Protein, Human (HEK293, His) O60259-1 (Q29-G260) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Keratosis

  • Actinic Keratosis

  • Hyperkeratosis
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Psoriasis
Granulomatous Angiitis

  • Vasculitis, Central Nervous System
Autosomal Recessive Congenital Ichthyosis

  • Lamellar Ichthyosis

  • Congenital Ichthyosiform Erythroderma

  • Li

  • Congenital Nonbullous Ichthyosiform Erythroderma

  • Arci

  • Congenital Lamellar Ichthyosis

  • Nonbullous Congenital Ichthyosiform Erythroderma

  • Cie

  • Congenital Non-Bullous Ichthyosiform Erythroderma

  • Erythrodermic Ichthyosis

  • Nbcie

  • Ncie

  • Non-Bullous Congenital Ichthyosiform Erythroderma

  • Collodion Baby

  • Ichthyosis, Lamellar

  • Non Bullous Congenital Ichthyosiform Erythroderma

  • Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form

  • Ichthyosiform Erythroderma, Congenital, Nonbullous, 1

  • Collodion Baby Syndrome

  • Ichthyoses, Lamellar

  • Nbie

  • Nonbullous Ichthyosiform Erythroderma

  • Classic Lamellar Ichthyosis

  • Ichthyosiform Erythroderma Nonbullous Congenital

  • Ichthyosiform Erythroderma Congenital

  • Ichthyosis, Congenital, Autosomal Recessive

  • Ichthyosiform Erythroderma, Congenital

  • Collodion Fetus

  • Non-Bullous Ichthyosiform Erythroderma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148949A Kallikrein 5-IN-2 TFA Inhibitor 99.53% Unkown

Orthologs Information

Species Symbol Source ID
Felis catus KLK8 VGNC VGNC:67968
Bos taurus KLK8 VGNC VGNC:30682
Mus musculus KLK8 MGD MGI:1343327
Rattus norvegicus KLK8 RGD RGD:1305998
Macaca mulatta KLK8 VGNC VGNC:74194
Others KLK8 NCBI