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Cat. No.: HY-109023

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Azeloprazole

Azeloprazole is an orally active proton pump inhibitor. Azeloprazole irreversibly binds to and blocks the proton pump (H⁺/K⁺-ATPase) on parietal cells, thereby inhibiting gastric acid secretion. Azeloprazole is primarily metabolized by the CYP3A4 enzyme, and its pharmacokinetics and acid-suppressive effects are independent of CYP2C19 activity. Azeloprazole can be used for research on acid-related diseases such as reflux esophagitis and gastroesophageal reflux disease.

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CAS No.: 955095-45-1
Formule: C₂₂H₂₇N₃O₄S
Masse moléculaire:429.53

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Azeloprazole Chemical Structure

CAS No.: 955095-45-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

In Vivo

Azeloprazole sodium (intraduodenal administration; single dose) inhibits Histamine (HY-B1204)-induced gastric acid secretion in a gastric fistula dog model, with a potency more than twice that of Esomeprazole^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Protocol for Pharmacokinetic Study

Chemical Information

CAS No. 955095-45-1
Masse moléculaire 429.53
Formule C₂₂H₂₇N₃O₄S
SMILES

CC(C(OCC1COC(C)(OC1)C)=C(C=N2)C)=C2C[S@](C3=NC4=CC=CC=C4N3)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Srebro J, et al. Formulation of Dosage Forms with Proton Pump Inhibitors: State of the Art, Challenges and Future Perspectives. Pharmaceutics. 2022 Sep 25;14(10):2043.

[2]. Kinoshita Y, et al. Efficacy and Safety Profile of Z-215 (Azeloprazole Sodium), a Proton Pump Inhibitor, Compared with Rabeprazole Sodium in Patients with Reflux Esophagitis: A Phase II, Multicenter, Randomized, Double-Blind, Comparative Study. Current therapeutic research, clinical and experimental. 2018;88:26-34.

[3]. Simadibrata DM, et al. Experimental drugs for erosive esophagitis: what is in the clinical development pipeline?. Expert opinion on investigational drugs. 2024 Oct;33(10):1009-1018.

[4]. Hunt RH, et al. Potent Acid Suppression with PPIs and P-CABs: What's New?. Current treatment options in gastroenterology. 2018 Dec;16(4):570-590.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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