Azeloprazole sodium
Azeloprazole sodium is an orally active proton pump inhibitor. Azeloprazole sodium irreversibly binds to and blocks the proton pump (H+/K+-ATPase) on parietal cells, thereby inhibiting gastric acid secretion. Azeloprazole sodium is primarily metabolized by the CYP3A4 enzyme, and its pharmacokinetics and acid-suppressive effects are independent of CYP2C19 activity. Azeloprazole sodium can be used for research on acid-related diseases such as reflux esophagitis and gastroesophageal reflux disease.
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- CAS. Nr.: 955095-47-3
- Formel: C22H26N3NaO4S
- Molecular Weight:451.51
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 955095-47-3
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Molecular Weight 451.51
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Formel C22H26N3NaO4S
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SMILES
O=[S@@](C1=NC2=CC=CC=C2[N-]1)CC3=NC=C(C)C(OCC4COC(C)(C)OC4)=C3C.[Na+]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Srebro J, et al. Formulation of Dosage Forms with Proton Pump Inhibitors: State of the Art, Challenges and Future Perspectives. Pharmaceutics. 2022 Sep 25;14(10):2043. [Content Brief]
[2]. Kinoshita Y, et al. Efficacy and Safety Profile of Z-215 (Azeloprazole Sodium), a Proton Pump Inhibitor, Compared with Rabeprazole Sodium in Patients with Reflux Esophagitis: A Phase II, Multicenter, Randomized, Double-Blind, Comparative Study. Current therapeutic research, clinical and experimental. 2018;88:26-34. [Content Brief]
[4]. Hunt RH, et al. Potent Acid Suppression with PPIs and P-CABs: What's New?. Current treatment options in gastroenterology. 2018 Dec;16(4):570-590. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Azeloprazole sodium Related Classifications
HY-19865 Related Classifications
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