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United States

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製品番号: HY-109023A

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Azeloprazole potassium

Azeloprazole potassium is an orally active proton pump inhibitor. Azeloprazole potassium irreversibly binds to and blocks the proton pump (H⁺/K⁺-ATPase) on parietal cells, thereby inhibiting gastric acid secretion. Azeloprazole potassium is primarily metabolized by the CYP3A4 enzyme, and its pharmacokinetics and acid-suppressive effects are independent of CYP2C19 activity. Azeloprazole potassium can be used for research on acid-related diseases such as reflux esophagitis and gastroesophageal reflux disease.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 955095-50-8
分子式: C₂₂H₂₇KN₃O₄S
分子量:468.63

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Azeloprazole potassium 構造式

CAS 番号: 955095-50-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体内実験

Azeloprazole sodium (intraduodenal administration; single dose) potassium inhibits Histamine (HY-B1204)-induced gastric acid secretion in a gastric fistula dog model, with a potency more than twice that of Esomeprazole^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Protocol for Pharmacokinetic Study

化学情報

CAS 番号 955095-50-8
分子量 468.63
分子式 C₂₂H₂₇KN₃O₄S
SMILES

S(CC1=C(C)C(OCC2COC(C)(C)OC2)=C(C)C=N1)(=O)C=3NC=4C(N3)=CC=CC4.[K]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Srebro J, et al. Formulation of Dosage Forms with Proton Pump Inhibitors: State of the Art, Challenges and Future Perspectives. Pharmaceutics. 2022 Sep 25;14(10):2043.

[2]. Kinoshita Y, et al. Efficacy and Safety Profile of Z-215 (Azeloprazole Sodium), a Proton Pump Inhibitor, Compared with Rabeprazole Sodium in Patients with Reflux Esophagitis: A Phase II, Multicenter, Randomized, Double-Blind, Comparative Study. Current therapeutic research, clinical and experimental. 2018;88:26-34.

[3]. Simadibrata DM, et al. Experimental drugs for erosive esophagitis: what is in the clinical development pipeline?. Expert opinion on investigational drugs. 2024 Oct;33(10):1009-1018.

[4]. Hunt RH, et al. Potent Acid Suppression with PPIs and P-CABs: What's New?. Current treatment options in gastroenterology. 2018 Dec;16(4):570-590.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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