Azido-PEG2-C2-sulfonic acid
Based on 1 Customer Validation
Azido-PEG2-C2-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-C2-sulfonic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 1817735-39-9
- Formula: C6H13N3O5S
- Molecular Weight:239.25
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
PEGs |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1817735-39-9
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Appearance Oil
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Molecular Weight 239.25
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Formula C6H13N3O5S
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Color Off-white to light yellow
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SMILES
[N-]=[N+]=NCCOCCOCCS(=O)(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (417.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.1797 mL | 20.8986 mL | 41.7973 mL | 104.4932 mL |
| 5 mM | 0.8359 mL | 4.1797 mL | 8.3595 mL | 20.8986 mL | |
| 10 mM | 0.4180 mL | 2.0899 mL | 4.1797 mL | 10.4493 mL | |
| 15 mM | 0.2786 mL | 1.3932 mL | 2.7865 mL | 6.9662 mL | |
| 20 mM | 0.2090 mL | 1.0449 mL | 2.0899 mL | 5.2247 mL | |
| 25 mM | 0.1672 mL | 0.8359 mL | 1.6719 mL | 4.1797 mL | |
| 30 mM | 0.1393 mL | 0.6966 mL | 1.3932 mL | 3.4831 mL | |
| 40 mM | 0.1045 mL | 0.5225 mL | 1.0449 mL | 2.6123 mL | |
| 50 mM | 0.0836 mL | 0.4180 mL | 0.8359 mL | 2.0899 mL | |
| 60 mM | 0.0697 mL | 0.3483 mL | 0.6966 mL | 1.7416 mL | |
| 80 mM | 0.0522 mL | 0.2612 mL | 0.5225 mL | 1.3062 mL | |
| 100 mM | 0.0418 mL | 0.2090 mL | 0.4180 mL | 1.0449 mL |
Azido-PEG2-C2-sulfonic acid Related Classifications
HY-140164 Related Classifications
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