BCN-linker-DXd 2
Based on 1 Customer Validation
BCN-linker-DXd 2 is a specialized antibody-drug conjugate (ADC) payload-linker complex carrying a derivative of the cytotoxic agent DXd (HY-13631D). BCN-linker-DXd 2 bears a BCN (bicyclononyne) group for click chemical bioconjugation, and can be used for ADC synthesis.
For research use only. We do not sell to patients.
- CAS No.: 2566530-81-0
- Formula: C108H128F2N16O31S2
- Molecular Weight:2248.39
-
Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
More
Biological Activity
BCN-linker-DXd 2 can form antibody-drug conjugates (ADCs) with azide-modified antibodies, after which the processing of tumor cells releases the active toxin payload via successive proteolytic hydrolysis and acid hydrolysis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2566530-81-0
-
Appearance Solid
-
Molecular Weight 2248.39
-
Formula C108H128F2N16O31S2
-
Color White to off-white
-
SMILES
[H][C@]1(CCC#CCC2)[C@]2([H])[C@H]1COC(NS(NCCOCCOC(NS(N(CCOC(N[C@@H](C(C)C)C(N[C@@H](C)C(NC3=CC=C(C=C3)COC(C)OCC(N[C@@H]4C5=C6C(C(N7C6)=CC([C@](O)(C(OC8)=O)CC)=C8C7=O)=NC9=CC(F)=C(C)C(CC4)=C95)=O)=O)=O)=O)CCOC(N[C@@H](C(C)C)C(N[C@@H](C)C(NC(C=C%10)=CC=C%10COC(C)OCC(N[C@@H]%11C%12=C%13C(C(N%14C%13)=CC([C@](O)(C(OC%15)=O)CC)=C%15C%14=O)=NC%16=CC(F)=C(C)C(CC%11)=C%16%12)=O)=O)=O)=O)(=O)=O)=O)(=O)=O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (44.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (271 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.4448 mL | 2.2238 mL | 4.4476 mL | 11.1191 mL |
| 5 mM | 0.0890 mL | 0.4448 mL | 0.8895 mL | 2.2238 mL | |
| 10 mM | 0.0445 mL | 0.2224 mL | 0.4448 mL | 1.1119 mL | |
| 15 mM | 0.0297 mL | 0.1483 mL | 0.2965 mL | 0.7413 mL | |
| 20 mM | 0.0222 mL | 0.1112 mL | 0.2224 mL | 0.5560 mL | |
| 25 mM | 0.0178 mL | 0.0890 mL | 0.1779 mL | 0.4448 mL | |
| 30 mM | 0.0148 mL | 0.0741 mL | 0.1483 mL | 0.3706 mL | |
| 40 mM | 0.0111 mL | 0.0556 mL | 0.1112 mL | 0.2780 mL |
BCN-linker-DXd 2 Related Classifications
HY-160098 Related Classifications
Powered by Bioz