BaF3
Definition:
BaF3 is a mouse Pro-B cell factor-dependent cell line derived from Bone marrow. Its stable in vitro growth supports reproducible mechanistic and pharmacological experiments. BaF3 is used to investigate apoptosis, cell proliferation, cell-cycle control, and DNA-damage responses in a controlled cellular system.
References:
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[1]. Li C, et al. Overexpression of Apg-2 increases cell proliferation and protects from oxidative damage in BaF3-BCR/ABL cells. International journal of oncology. 2010;36(4):899-904. [Content Brief]
[2]. Gupta P, et al. Preclinical development of a novel BCR-ABL T315I inhibitor against chronic myeloid leukemia. Cancer letters. 2020;472:132-141. [Content Brief]
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