E-type cyclins/cyclin E

Definition:

E-type cyclins/cyclin E, represent key components of the core cell cycle machinery. In mammalian cells, two E-type cyclins, E1 and E2, activate cyclin-dependent kinase 2 (CDK2) and drive cell cycle progression by phosphorylating several cellular proteins.

References:

[1]. Chen Chu, et al. Cyclin E in normal physiology and disease states. Trends Cell Biol. 2021 Sep;31(9):732-746. [Content Brief]

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