2. PROTAC
  3. PROTAC Linkers
  4. Biotin-PEG3-OH

Biotin-PEG3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Biotin-PEG3-OH Chemical Structure

Biotin-PEG3-OH Chemical Structure

CAS No. : 1263044-40-1

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Biotin-PEG3-OH Related Antibodies

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Description

Biotin-PEG3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Biotin-PEG3-OH Related Antibodies
Molecular Weight

375.48

Formula

C16H29N3O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCOCCOCCO)CCCCC1SCC(C1N2)NC2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (665.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6633 mL 13.3163 mL 26.6326 mL
5 mM 0.5327 mL 2.6633 mL 5.3265 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6633 mL 13.3163 mL 26.6326 mL 66.5814 mL
5 mM 0.5327 mL 2.6633 mL 5.3265 mL 13.3163 mL
10 mM 0.2663 mL 1.3316 mL 2.6633 mL 6.6581 mL
15 mM 0.1776 mL 0.8878 mL 1.7755 mL 4.4388 mL
20 mM 0.1332 mL 0.6658 mL 1.3316 mL 3.3291 mL
25 mM 0.1065 mL 0.5327 mL 1.0653 mL 2.6633 mL
30 mM 0.0888 mL 0.4439 mL 0.8878 mL 2.2194 mL
40 mM 0.0666 mL 0.3329 mL 0.6658 mL 1.6645 mL
50 mM 0.0533 mL 0.2663 mL 0.5327 mL 1.3316 mL
60 mM 0.0444 mL 0.2219 mL 0.4439 mL 1.1097 mL
80 mM 0.0333 mL 0.1665 mL 0.3329 mL 0.8323 mL
100 mM 0.0266 mL 0.1332 mL 0.2663 mL 0.6658 mL
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Biotin-PEG3-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biotin-PEG3-OH1263044-40-1PROTAC LinkersInhibitorinhibitorinhibit

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