Biotin-PEG4-SH
Based on 1 Customer Validation
Biotin-PEG4-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 2762393-22-4
- Formula: C20H37N3O6S2
- Molecular Weight:479.65
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2762393-22-4
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Appearance Oil
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Molecular Weight 479.65
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Formula C20H37N3O6S2
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Color Off-white to light yellow
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SMILES
O=C(NCCOCCOCCOCCOCCS)CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (208.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0849 mL | 10.4243 mL | 20.8485 mL | 52.1213 mL |
| 5 mM | 0.4170 mL | 2.0849 mL | 4.1697 mL | 10.4243 mL | |
| 10 mM | 0.2085 mL | 1.0424 mL | 2.0849 mL | 5.2121 mL | |
| 15 mM | 0.1390 mL | 0.6950 mL | 1.3899 mL | 3.4748 mL | |
| 20 mM | 0.1042 mL | 0.5212 mL | 1.0424 mL | 2.6061 mL | |
| 25 mM | 0.0834 mL | 0.4170 mL | 0.8339 mL | 2.0849 mL | |
| 30 mM | 0.0695 mL | 0.3475 mL | 0.6950 mL | 1.7374 mL | |
| 40 mM | 0.0521 mL | 0.2606 mL | 0.5212 mL | 1.3030 mL | |
| 50 mM | 0.0417 mL | 0.2085 mL | 0.4170 mL | 1.0424 mL | |
| 60 mM | 0.0347 mL | 0.1737 mL | 0.3475 mL | 0.8687 mL | |
| 80 mM | 0.0261 mL | 0.1303 mL | 0.2606 mL | 0.6515 mL | |
| 100 mM | 0.0208 mL | 0.1042 mL | 0.2085 mL | 0.5212 mL |
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