2. PROTAC
  3. PROTAC Linkers
  4. Biotin-PEG4-SH

Biotin-PEG4-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Biotin-PEG4-SH Chemical Structure

Biotin-PEG4-SH Chemical Structure

CAS No. : 2762393-22-4

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5 mg USD 260 In-stock
10 mg USD 420 In-stock
25 mg USD 840 In-stock
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Based on 1 publication(s) in Google Scholar

Biotin-PEG4-SH Related Antibodies

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Description

Biotin-PEG4-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Biotin-PEG4-SH Related Antibodies
Molecular Weight

479.65

Formula

C20H37N3O6S2
CAS No.
Appearance

Oil

Color

Off-white to light yellow

SMILES

O=C(NCCOCCOCCOCCOCCS)CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (208.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0849 mL 10.4243 mL 20.8485 mL
5 mM 0.4170 mL 2.0849 mL 4.1697 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0849 mL 10.4243 mL 20.8485 mL 52.1213 mL
5 mM 0.4170 mL 2.0849 mL 4.1697 mL 10.4243 mL
10 mM 0.2085 mL 1.0424 mL 2.0849 mL 5.2121 mL
15 mM 0.1390 mL 0.6950 mL 1.3899 mL 3.4748 mL
20 mM 0.1042 mL 0.5212 mL 1.0424 mL 2.6061 mL
25 mM 0.0834 mL 0.4170 mL 0.8339 mL 2.0849 mL
30 mM 0.0695 mL 0.3475 mL 0.6950 mL 1.7374 mL
40 mM 0.0521 mL 0.2606 mL 0.5212 mL 1.3030 mL
50 mM 0.0417 mL 0.2085 mL 0.4170 mL 1.0424 mL
60 mM 0.0347 mL 0.1737 mL 0.3475 mL 0.8687 mL
80 mM 0.0261 mL 0.1303 mL 0.2606 mL 0.6515 mL
100 mM 0.0208 mL 0.1042 mL 0.2085 mL 0.5212 mL
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Biotin-PEG4-SH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biotin-PEG4-SH2762393-22-4PROTAC LinkersInhibitorinhibitorinhibit

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