bisSP1
Based on 1 Customer Validation
bisSP1 is an antibody-drug conjugate linker (ADC Linkers). bisSP1 is also a click chemistry reagent that undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 2253947-15-6
- Formula: C12H23N9O2
- Molecular Weight:325.37
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
bisSP1 (2253947-15-6) acts as an ADC linker to conjugate with N297Q-mutated anti-FGFR2b antibodies (mAb1, mAb2) and drug linker 3, forming intact antibody-drug conjugates[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2253947-15-6
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Appearance Liquid
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Molecular Weight 325.37
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Formula C12H23N9O2
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Color Colorless to light yellow
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SMILES
[N-]=[N+]=NCCC(N[C@@H](CCCCN)C(NCCCN=[N+]=[N-])=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (307.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0734 mL | 15.3671 mL | 30.7342 mL | 76.8356 mL |
| 5 mM | 0.6147 mL | 3.0734 mL | 6.1468 mL | 15.3671 mL | |
| 10 mM | 0.3073 mL | 1.5367 mL | 3.0734 mL | 7.6836 mL | |
| 15 mM | 0.2049 mL | 1.0245 mL | 2.0489 mL | 5.1224 mL | |
| 20 mM | 0.1537 mL | 0.7684 mL | 1.5367 mL | 3.8418 mL | |
| 25 mM | 0.1229 mL | 0.6147 mL | 1.2294 mL | 3.0734 mL | |
| 30 mM | 0.1024 mL | 0.5122 mL | 1.0245 mL | 2.5612 mL | |
| 40 mM | 0.0768 mL | 0.3842 mL | 0.7684 mL | 1.9209 mL | |
| 50 mM | 0.0615 mL | 0.3073 mL | 0.6147 mL | 1.5367 mL | |
| 60 mM | 0.0512 mL | 0.2561 mL | 0.5122 mL | 1.2806 mL | |
| 80 mM | 0.0384 mL | 0.1921 mL | 0.3842 mL | 0.9604 mL | |
| 100 mM | 0.0307 mL | 0.1537 mL | 0.3073 mL | 0.7684 mL |
bisSP1 Related Classifications
HY-147325 Related Classifications
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