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Cat. No.: HY-161706

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c-Fms-IN-15

c-Fms-IN-15 (compound 8g) is a potent inhibitor of FMS kinase, with the IC₅₀ of 563 nM.

For research use only. We do not sell to patients.

CAS No.: 3047930-25-3
Formula: C₂₉H₂₈F₃N₇O₂
Molecular Weight:563.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

c-Fms-IN-15 Chemical Structure

CAS No.: 3047930-25-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

c-Fms-IN-15 (compound 8g) is a potent inhibitor of FMS kinase, with the IC₅₀ of 563 nM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
BMDM	IC₅₀	56 nM Compound: 8g	Inhibition of CSF-1-induced C57BL6 mouse BMDM cell growth preincubated for 1 hr followed by CSF-1 addition and measured after 5 hrs by alamar blue assay Inhibition of CSF-1-induced C57BL6 mouse BMDM cell growth preincubated for 1 hr followed by CSF-1 addition and measured after 5 hrs by alamar blue assay	[PMID: 38850857]
Hep 3B2	IC₅₀	1.63 μM Compound: 8g	Antiproliferative activity against human Hep3B cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human Hep3B cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 38850857]
HepG2	IC₅₀	1.48 μM Compound: 8g	Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 38850857]
HS27	IC₅₀	9.4 μM Compound: 8g	Cytotoxicity against human HS27 cells assessed as reduction in cell growth measured after 48 hrs by MTT assay Cytotoxicity against human HS27 cells assessed as reduction in cell growth measured after 48 hrs by MTT assay	[PMID: 38850857]
WI-38	IC₅₀	19.1 μM Compound: 8g	Cytotoxicity against human WI-38 cells assessed as reduction in cell growth measured after 48 hrs by MTT assay Cytotoxicity against human WI-38 cells assessed as reduction in cell growth measured after 48 hrs by MTT assay	[PMID: 38850857]

Chemical Information

CAS No. 3047930-25-3
Molecular Weight 563.57
Formula C₂₉H₂₈F₃N₇O₂
SMILES

O=C(C1=CC(C2=CC=C(NC(NC3=CC=C(N4CCN(C)CC4)C(C(F)(F)F)=C3)=O)C=C2)=NC5=CC=CN=C15)NC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Anusha Sebastian, et al. Design, synthesis, biological evaluation, and in silico studies of novel pyridopyridine derivatives as anticancer candidates targeting FMS kinase. Eur J Med Chem. 2024 Aug 5:274:116557. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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