S100a1 - S100 calcium binding protein A1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 295214

Summary

Enables calcium ion binding activity; calcium-dependent protein binding activity; and identical protein binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of voltage-gated Calcium Channel activity. Located in M band; Z disc; and neuron projection. Orthologous to human S100A1 (S100 calcium binding protein A1). [provided by Alliance of Genome Resources, Apr 2022]

S100a1 Products (1)

mRNA Protein Name
NM_001007636.3 NP_001007637.1 protein S100-A1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
16169012 RGD
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
10567243 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
16169012 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
14638689 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
12619862 RGD
involved in positive regulation of voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
19657060 RGD
Cellular Component GO Annotation Evidence References Source
located in A band IDA
IDA: Inferred from direct assay
11156445 RGD
located in I band IDA
IDA: Inferred from direct assay
11156445 RGD
located in M band IDA
IDA: Inferred from direct assay
11156445 RGD
located in Z disc IDA
IDA: Inferred from direct assay
11156445 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein S100-A1

  • S-100 protein alpha chain

  • S-100 protein subunit alpha

S100a1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
S100a1 P35467 FKBP4 Homo sapiens Q02790
Anti Bait CoIP
14638689
Cross
S100a1 P35467 FKBP4 Homo sapiens Q02790
SPR
14638689
Cross
S100a1 P35467 HSP90AA1 Homo sapiens P07900
SPR
14638689
Cross
S100a1 P35467 HSP90AA1 Homo sapiens P07900
Anti Bait CoIP
14638689
Cross
S100a1 P35467 HSP90AA1 Homo sapiens P07900
Pull Down
14638689
Cross
S100a1 P35467 HSPA1A Homo sapiens P08107
SPR
14638689
Cross
S100a1 P35467 PPID Bos taurus P26882
Anti Bait CoIP
14638689
Cross
S100a1 P35467 PPID Bos taurus P26882
Pull Down
14638689
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-146695 S100P-IN-1 Inhibitor 99.81% Unkown
HY-103636 PROTAC Sirt2 Degrader-1 Inhibitor 99.09% Unkown
HY-16918A Heptamidine dimethanesulfonate Inhibitor 99.12% Unkown
HY-RS16310 S100a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-16918 Heptamidine / Unkown
HY-RS12371 S100A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-103636R PROTAC Sirt2 Degrader-1 (Standard) Inhibitor / Unkown
HY-RS18011 S100a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25212 S100a13 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens S100a1 NCBI NCBI:6271