Cldn5 - claudin 5 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 65131

Summary

Predicted to enable identical protein binding activity. Involved in myelination and response to ethanol. Located in Schmidt-Lanterman incisure; lateral plasma membrane; and paranode region of axon. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human CLDN5 (Claudin 5). [provided by Alliance of Genome Resources, Apr 2022]

Cldn5 Products (1)

mRNA Protein Name
NM_031701.2 NP_113889.1 claudin-5

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in myelination IPI
IPI: Inferred from physical interaction
12403818 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
17889313 RGD
Cellular Component GO Annotation Evidence References Source
located in Schmidt-Lanterman incisure IDA
IDA: Inferred from direct assay
12403818 RGD
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
19929946 RGD
located in paranode region of axon IDA
IDA: Inferred from direct assay
12403818 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

claudin-5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15651 Alvelestat Activator 99.87% Yes
HY-W015777 4-Methoxybenzyl alcohol Activator 99.93% Unkown
HY-15651A Alvelestat tosylate Activator / Unkown
HY-15651B Alvelestat hydrochloride Activator / Unkown
HY-15651R Alvelestat (Standard) Activator / Unkown
HY-15651S Alvelestat-13C,d3 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cldn5 NCBI NCBI:7122