L-760735
Based on 1 Customer Validation
L-760735 is a high affinity, selective and orally active NK1 receptor antagonist with an IC50 of 0.19 nM for human NK1 receptors. L-760735 exhibits anxiolytic and antidepressant-like effects.
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 188923-01-5
- Formula: C26H29ClF7N5O2
- Molecular Weight:611.98
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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hNK1 0.19 nM (IC50) |
Chemical Information
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CAS No. 188923-01-5
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Appearance Solid
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Molecular Weight 611.98
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Formula C26H29ClF7N5O2
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Color Off-white to light yellow
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SMILES
C[C@H](C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)O[C@@H](OCC2)[C@@](C3=CC=C(C=C3)F)([H])N2CC4=C(N=NN4)CN(C)C.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 30.6 mg/mL (50.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6340 mL | 8.1702 mL | 16.3404 mL | 40.8510 mL |
| 5 mM | 0.3268 mL | 1.6340 mL | 3.2681 mL | 8.1702 mL | |
| 10 mM | 0.1634 mL | 0.8170 mL | 1.6340 mL | 4.0851 mL | |
| 15 mM | 0.1089 mL | 0.5447 mL | 1.0894 mL | 2.7234 mL | |
| 20 mM | 0.0817 mL | 0.4085 mL | 0.8170 mL | 2.0426 mL | |
| 25 mM | 0.0654 mL | 0.3268 mL | 0.6536 mL | 1.6340 mL | |
| 30 mM | 0.0545 mL | 0.2723 mL | 0.5447 mL | 1.3617 mL | |
| 40 mM | 0.0409 mL | 0.2043 mL | 0.4085 mL | 1.0213 mL |
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