SCH 54388
SCH 54388 is an orally active metabolite of Felbamate (HY-B0184). SCH 54388 significantly attenuates the functional impairment effects induced by Scopolamine (HY-N0296) or Dizocilpine (HY-15084B). SCH 54388 can be used in research related to cognitive impairment.
For research use only. We do not sell to patients.
- CAS No.: 25451-53-0
- Formula: C10H13NO3
- Molecular Weight:195.22
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vivo
SCH 54388 (0.01-0.1 mg/kg; s.c.; single administration) reverses dizocilpine-induced cognitive impairment in CF-1 mice[1].
SCH 54388 (10-100 mg/kg; s.c.; single administration) produces statistically significant analgesic effects in CF-1 mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Charles River BALB (male, 25-30 g, scopolamine-induced cognitive impairment)[1]
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Dosage:0.1 mg/kg; 1.0 mg/kg; 10 mg/kg
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Administration:s.c.; single dose
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Result:Produced mean reentry latencies statistically greater than scopolamine alone.
Demonstrated a statistically significant overall treatment effect.
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Animal Model:Charles River BALB (male, 25-30 g, scopolamine-induced cognitive impairment)[1]
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Dosage:0.1 mg/kg; 1.0 mg/kg; 10 mg/kg
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Administration:p.o.; single dose
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Result:Produced mean reentry latencies statistically greater than scopolamine alone.
Demonstrated a statistically significant overall treatment effect.
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Animal Model:Charles River CF-1 (male, 25-30 g, dizocilpine-induced cognitive impairment)[1]
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Dosage:0.01 mg/kg; 0.1 mg/kg
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Administration:s.c.; single dose
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Result:Produced mean reentry latencies statistically greater than dizocilpine alone.
Demonstrated a statistically significant overall treatment effect.
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Animal Model:Charles River CF-1 (male, 25-30 g)[1]
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Dosage:10 mg/kg; 100 mg/kg
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Administration:s.c.; single dose
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Result:Produced statistically significant increases in mean escape jump latencies compared to vehicle-treated animals.
Chemical Information
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CAS No. 25451-53-0
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Molecular Weight 195.22
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Formula C10H13NO3
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SMILES
O=C(N)OCC(CO)C1=CC=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SCH 54388 Related Classifications
HY-123280 Related Classifications
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