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Cat. No.: HY-162636

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5HT6-ligand-2

5HT6-ligand-2 (compound 15) is a potent 5-HT₆ inhibitor with K_i values of 3.4, 15 nM for 5-HT6, SERT, respectively. 5HT6-ligand-2 shows neuroprotection. 5HT6-ligand-2 has the potential for the research of dementia.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₂₉H₂₈N₆O
Masse moléculaire:476.57

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

5HT6-ligand-2 Chemical Structure

Stock

Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

^[1]

5-HT₆ Receptor

Voir tous les produits spécifiques à Isoform 5-HT Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	83 μM Compound: 15	Hepatotoxicity in human HepG2 cells incubated for 24 hrs by PrestoBlue reagent based assay Hepatotoxicity in human HepG2 cells incubated for 24 hrs by PrestoBlue reagent based assay	[PMID: 38901106]
HT-22	IC₅₀	>100 μM Compound: 15	Neurotoxicity in mouse HT-22 cells incubated for 24 hrs by PrestoBlue reagent based assay Neurotoxicity in mouse HT-22 cells incubated for 24 hrs by PrestoBlue reagent based assay	[PMID: 38901106]

In Vivo

BET-IN-26 (compound 13a) (10, 100 mg/kg; p.o.) decreases the LPS (HY-D1056) induced serum levels of IL-6 and MCP-1 in a dose-dependent manner in mice^[1].
Pharmacokinetic Parameters (2.5 mg/kg; i.p.; Male Wistar rats)^[1].

Parameter	Serum	Brain
C_max (ng/ml(g))	45.21	3.78
t_max (min)	30	30
l_z (min^-1)	0.0099	0.0072
t_0.5 (min)	70.08	96.71
V_z/F (l/kg)	55.87	-
CL/F (l/min/kg)	0.55	-
AUC_(0-inf) (ng/mL*min)	4542.15	606.48
MRT (min)	104.27	152.35

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

230-260 g, 8 weeks old Male Wistar rats (MK-801-induced memory impairment)^[1]
Dosage:

2.5, 5, 7.5 mg/kg
Administration:

I.p.; 30 min before testing
Result:

Significantly reduced immobility time by 30.5 % and increased climbing behaviors by 63 %, without affecting the duration of swimming at 5 mg/kg.

Chemical Information

Masse moléculaire 476.57
Formule C₂₉H₂₈N₆O
SMILES

O=C1N(CC2=CC=CC=C2)C3=CC=CC(N(CC4)CCN4CCC5=CNC6=C5C=C(C#N)C=C6)=C3N1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Siwek A, et al. Dual 5-HT6/SERT ligands for mitigating neuropsychiatric symptoms of dementia exerting neuroprotection against amyloid-β toxicity, memory preservation, and antidepressant-like properties. Eur J Med Chem. 2024 Sep 5;275:116601. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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