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Calcipotriol monohydrate

49 Cited Publications

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Based on 49 publication(s) in Google Scholar

Calcipotriol monohydrate is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.

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Pureté: 99.95%
CAS No.: 147657-22-5
Formule: C₂₇H₄₂O₄
Masse moléculaire:430.62

Stockage:

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Calcipotriol monohydrate Chemical Structure

CAS No.: 147657-22-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
- Essai clinique
Chemical Information
Publications (49)
Solvant et solubilité
- In Vitro
- In Vivo
Protocole
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Calcipotriol monohydrate is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.

IC₅₀ & Target

vitamin D receptor^[1]

In Vitro

When NHEK cells are not stimulated with IL-17A or IL-22, Calcipotriol slightly enhances (0.2 nM) IL-8 mRNA expression or has no effect (2-20 nM). The addition of IL-17A and IL-22 markedly increased the mRNA expression of IL-8, confirming our previous study. This enhanced IL-8 mRNA expression is suppressed by Calcipotriol at 2, 20 and 40 nM in a dose dependent manner^[1]. Treatment of natural killer (NK) cells with drugs modulates their expression of NK cytotoxicity receptors or KIR. Human NK cells are pre-treated with 100, 10 or 1 ng/mL of 1,25(OH)₂D₃, Calcipotriol or FTY720 for 4 h. All three concentrations of 1,25(OH)₂D₃, Calcipotriol and FTY720 significantly up-regulate the expression of NKp30 on the surface of NK cells after 4 h incubation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

One out of the 32 animals in each of the groups has died, except for the Diclofenac plus DFMO plus Calcipotriol group, where all animals survived. Survival is equally distributed between the groups. The weight gain is significantly smaller in the groups treated with Diclofenac plus Calcipotriol (p=0.018) and Diclofenac plus DFMO plus Calcipotriol (p=0.002) compare with placebo (linear regression model)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 147657-22-5
Appearance Solid
Masse moléculaire 430.62
Formule C₂₇H₄₂O₄
Color White to off-white
SMILES

O[C@H](C/1=C)C[C@H](O)CC1=C\C=C2[C@@](CC[C@@H]3[C@@H](/C=C/[C@@H](O)C4CC4)C)([H])[C@]3(C)CCC\2.O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Publications (49)

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Immunity

Intestinal dysbiosis exacerbates skin inflammation via microbial metabolite-driven Th2 cell differentiation. [Abstract]

2026 Jun 9;59(6):1545-1560.e6. PMID: 41997160
Immunity

Metabolic coordination between skin epithelium and type 17 immunity sustains chronic skin inflammation. [Abstract]

2024 May 14:S1074-7613(24)00227-9. PMID: 38772365
Bioact Mater

Food-derived β-lactoglobulin nanofibrils: An efficacy, safe, and scalable solution to overcome oral insulin delivery challenges. [Abstract]

2025 Nov 25:57:646-659. PMID: 41377894
Adv Funct Mater

2025 May 27.
Nat Commun

Hydrogel dressing integrating FAK inhibition and ROS scavenging for mechano-chemical treatment of atopic dermatitis. [Abstract]

2023 Apr 29;14(1):2478. PMID: 37120459
Sci Adv

N6-methyladenosine modification-tuned lipid metabolism controls skin immune homeostasis via regulating neutrophil chemotaxis. [Abstract]

2024 Oct 4;10(40):eadp5332. PMID: 39356764

Calcipotriol monohydrate purchased from MedChemExpress. Usage Cited in: Sci Adv. 2024 Oct 4;10(40):eadp5332. [Abstract]

Immunofluorescence staining of ELOVL6 in the MC903-treated skin from WT or cKO mice (I) or from C57BL6/J mice with MP3C or EtOH application (J). For the MC903-induced AD mouse model, 1 nmol of Calcipotriol (MC903), dissolved in 10 μl of ethanol, was applied daily to the ears of 7-week-old mice. For dorsal application, 4 nmol of MC903, dissolved in 40 μl of ethanol, was applied daily to the backs of the mice for the specified duration.
J Allergy Clin Immunol

IL-31-generating network in atopic dermatitis comprising macrophages, basophils, thymic stromal lymphopoietin, and periostin. [Abstract]

2023 Mar;151(3):737-746.e6. PMID: 36410530

Calcipotriol monohydrate purchased from MedChemExpress. Usage Cited in: J Allergy Clin Immunol. 2023 Mar;151(3):737-746.e6. [Abstract]

A significant number of infiltrating cells express both IL-31 (green) and MOMA-2 (red) in Calcipotriol (MC903)-treated mice.

Calcipotriol monohydrate purchased from MedChemExpress. Usage Cited in: J Allergy Clin Immunol. 2023 Mar;151(3):737-746.e6. [Abstract]

Immunofluorescence staining. MC903 (Calcipotriol; 2 nmol/25 μL ethanol, applied to the earlobes once daily for 9 consecutive days)-treated mice show significant positive staining reactions for TSLP (green) at the epidermis (Fig, B) and periostin (green) in the dermis (Fig, C).

Calcipotriol monohydrate purchased from MedChemExpress. Usage Cited in: J Allergy Clin Immunol. 2023 Mar;151(3):737-746.e6. [Abstract]

Macroscopic and histopathological findings. Treatment of the earlobes with MC903 (Calcipotriol; 2 nmol/25 μL ethanol, applied to the earlobes once daily for 9 consecutive days) induces AD-like skin inflammation (left panel) with histopathological hyperkeratosis and acanthosis, accompanied by massive infiltrates in the dermis (middle panel) and TUG8⁺ basophils (red) (right panel).
J Exp Med

ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice. [Abstract]

2021 Dec 6;218(12):e20210639. PMID: 34813654
Cell Death Dis

A novel function of NLRP3 independent of inflammasome as a key transcription factor of IL-33 in epithelial cells of atopic dermatitis. [Abstract]

2021 Sep 24;12(10):871. PMID: 34561424
J Cachexia Sarcopenia Muscle

The Effects of Vitamin D on Muscle Strength Are Influenced by Testosterone Levels. [Abstract]

2025 Feb;16(1):e13733. PMID: 39957010

Calcipotriol monohydrate purchased from MedChemExpress. Usage Cited in: J Cachexia Sarcopenia Muscle. 2025 Feb;16(1):e13733. [Abstract]

Calcipotriol (cal, 60 μg/kg; i.p., three times a week) decreases the proportion of fibres with a CSA of 200-400 μm² and increases the proportion of fibres with a CSA of 1000-1400 μm² in male SKO mice, whereas it does not affect female mice.
Proc Natl Acad Sci U S A

Treg cells require Izumo1R to regulate γδT cell-driven inflammation in the skin. [Abstract]

2023 Apr 4;120(14):e2221255120. PMID: 36972453
Int J Biol Macromol

Bacterial cellulose membrane integrating phase-transited lysozyme nanofilm loaded with biguanides for dressing treatment of atopic dermatitis. [Abstract]

2025 Aug 21;323(Pt 1):147047. PMID: 40848785
Acta Pharmacol Sin

Differential regulation of pruritic sensation and emotion by cannabinoid type 1 receptors on mPFC glutamatergic and GABAergic neurons. [Abstract]

2025 Apr;46(4):904-921. PMID: 39663420
Acta Pharmacol Sin

Calcipotriol abrogates cancer-associated fibroblast-derived IL-8-mediated oxaliplatin resistance in gastric cancer cells via blocking PI3K/Akt signaling. [Abstract]

2023 Jan;44(1):178-188. PMID: 35676532

Calcipotriol monohydrate purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2023 Jan;44(1):178-188. [Abstract]

Calcipotriol (Cal, 500 µM; 24 h) significantly stimulates VDR activation in HGC27 and AGS cells, but not in CAFs.
Phytomedicine

Reversal of BCAA-driven inflammatory senescence by traditional herbal oil prevents atopic dermatitis relapse. [Abstract]

2025 Oct 20:148:157425. PMID: 41161187
Phytomedicine

A tri-compound formula comprising Ginsenoside Rg1, tetrandrine and icariin alleviates atopic dermatitis symptoms in a mouse model. [Abstract]

2025 Apr 7:141:156737. PMID: 40222169
Free Radic Biol Med

Prolactin drives the pathogenic amplification of atopic dermatitis by promoting CCL17 secretion through activation of the PI3K/AKT pathway. [Abstract]

2026 Aug 1:251:199-211. PMID: 42009143
Free Radic Biol Med

PN-CeO2 as a potential therapeutic agent for atopic dermatitis: Antioxidant and anti-inflammatory effects. [Abstract]

2025 Nov:239:540-551. PMID: 40782974
J Transl Med

Bifidobacterium animalis subsp. Lactis BX-BC08 modulates gut microbiota and secretes alpha-Ketoglutaric acid to alleviate MC903-induced atopic dermatitis. [Abstract]

2025 Jul 10;23(1):768. PMID: 40640914
Cell Rep

Macrophage autophagy deficiency-induced CEBPB accumulation alleviates atopic dermatitis via impairing M2 polarization. [Abstract]

2023 Nov 13;42(11):113430. PMID: 37963021
Phytother Res

Sappanone A Exerted Strong Anti-Inflammatory Effects in the Treatment of Atopic Dermatitis Through IL-21R-Mediated JAK1/STAT3 Pathway. [Abstract]

2025 Nov 14. PMID: 41236101
Cell Mol Life Sci

Guided monocyte fate to FRβ/CD163+ S1 macrophage antagonises atopic dermatitis via fibroblastic matrices in mouse hypodermis. [Abstract]

2024 Dec 25;82(1):14. PMID: 39720957
J Invest Dermatol

An S100A8/A9 Neutralizing Antibody Potently Ameliorates Contact Hypersensitivity and Atopic Dermatitis Symptoms. [Abstract]

2025 Aug;145(8):1930-1945.e3. PMID: 39848567
J Invest Dermatol

TRPV3-Activated PARP1/AIFM1/MIF Axis through Oxidative Stress Contributes to Atopic Dermatitis. [Abstract]

2024 May 30:S0022-202X(24)00384-1. PMID: 38823435
J Invest Dermatol

Retracing from Outcomes to Causes: NRF2-Driven GSTA4 Transcriptional Regulation Controls Chronic Inflammation and Oxidative Stress in Atopic Dermatitis Recurrence. [Abstract]

2024 Jun 13:S0022-202X(24)01735-4. PMID: 38879155
J Invest Dermatol

Mast cells Initiate Type 2 Inflammation via Tryptase Released by MRGPRX2/MrgprB2 Activation in Atopic Dermatitis. [Abstract]

2024 Jan;144(1):53-62.e2. PMID: 37482287
J Invest Dermatol

Extracellular Vesicles of Commensal Skin Microbiota Alleviate Cutaneous Inflammation in Atopic Dermatitis Mouse Model by Re-Establishing Skin Homeostasis. [Abstract]

2025 Feb;145(2):312-322.e9. PMID: 36907322
Biochem Pharmacol

Vitamin D receptor agonists inhibit liver fibrosis by disrupting the interaction between hepatic stellate cells and neutrophil extracellular traps. [Abstract]

2025 Jun 24:240:117059. PMID: 40571206
J Ethnopharmacol

Elephantopus scaber suppresses ConA-induced T cell activation by inhibiting NF-κB and Ca2+/NFAT signaling. [Abstract]

2026 May 10:362:121364. PMID: 41687940
J Ethnopharmacol

Elephantopus scaber attenuates MC903-caused atopic dermatitis and decreases TNF-α/IFN-γ-induced chemokines by suppressing MKP-1-mediated AP-1 signaling in keratinocytes. [Abstract]

2025 Aug 29:352:120267. PMID: 40633861
J Ethnopharmacol

Calycosin enhances Treg differentiation for alleviating skin inflammation in atopic dermatitis. [Abstract]

2024 May 23:326:117883. PMID: 38331120
Int J Pharm

FAP-targeting biomimetic nanosystem to restore the activated cancer-associated fibroblasts to quiescent state for breast cancer radiotherapy. [Abstract]

2025 Jan 7:125190. PMID: 39788396
Int J Mol Sci

Vitamin D and Its Analogues Decrease Amyloid-β (Aβ) Formation and Increase Aβ-Degradation. [Abstract]

2017 Dec 19;18(12). pii: E2764. PMID: 29257109
Front Pharmacol

Schizonepeta tenuifolia Briq-Saposhnikovia divaricata decoction alleviates atopic dermatitis via downregulating macrophage TRPV1. [Abstract]

2024 Aug 27:15:1413513. PMID: 39257398
Front Pharmacol

Calcipotriol Inhibits NLRP3 Signal Through YAP1 Activation to Alleviate Cholestatic Liver Injury and Fibrosis. [Abstract]

2020 Mar 31;11:200. PMID: 32296329
Int Immunopharmacol

BoNT-A amelliorates itch sensitization in atopic dermatitis mice by inhibiting histamine release. [Abstract]

2026 Aug 1:182:116774. PMID: 42102607
Eur J Pharmacol

A multi-target combinatorial therapy of MDBA alleviates atopic dermatitis via synchronized immunosuppression and barrier repair. [Abstract]

2026 Mar 28:1019:178729. PMID: 41802486
Int Immunopharmacol

Fecal microbiota transplantation affects the recovery of AD-skin lesions and enhances gut microbiota homeostasis. [Abstract]

2023 May:118:110005. PMID: 36924566
Nanomedicine

Nanoemulsion loaded gel for topical co-delivery of clobitasol propionate and calcipotriol in psoriasis. [Abstract]

2017 May;13(4):1473-1482. PMID: 28259803
J Inflamm Res

Neural-Inflammation Mechanism of Spinal Palmitic Acid Promoting Atopic Dermatitis in Mice. [Abstract]

2025 Jun 17:18:7907-7919. PMID: 40546406
J Integr Med

Prim-O-glucosylcimifugin mitigates atopic dermatitis by inhibiting Th2 differentiation through LCK phosphorylation modulation. [Abstract]

2025 May;23(3):309-319. PMID: 40253253
Virol Sin

Antiviral activity of vitamin D derivatives against severe fever with thrombocytopenia syndrome virus in vitro and in vivo. [Abstract]

2024 Aug 19:S1995-820X(24)00134-2. PMID: 39168248
Sci Rep

A subpopulation of projections from the parabrachial nucleus to the central amygdala mediates itch. [Abstract]

2025 Jul 21;15(1):26432. PMID: 40691451
Cytokine

Calcipotriol suppresses GPX4-mediated ferroptosis in OA chondrocytes by blocking the TGF-β1 pathway. [Abstract]

2023 Nov:171:156382. PMID: 37782985
Med Hypotheses

SARS-CoV-2 might transmit through the skin while the skin barrier function could be the mediator. [Abstract]

2022 Feb:159:110752. PMID: 35002019
Res Sq

2026 Jan 12.
SSRN

2025 Dec 30.
bioRxiv

2020 Jul.
Patent

US20150283231A1.

Solvant et solubilité

In Vitro:

Ethanol : 100 mg/mL (232.22 mM; Need ultrasonic)

DMSO : 100 mg/mL (232.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3222 mL

11.6112 mL

23.2223 mL

5 mM

0.4644 mL

2.3222 mL

4.6445 mL

10 mM

0.2322 mL

1.1611 mL

2.3222 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline

Solubility: 5 mg/mL (11.61 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 5 mg/mL (11.61 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% EtOH 90% Corn Oil

Solubility: ≥ 5 mg/mL (11.61 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Protocol 4

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.81 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 5

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (5.81 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 6

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (5.81 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Protocol 7

Add each solvent one by one: 5% DMSO 40% PEG300 5% Tween-80 50% Saline

Solubility: 2.5 mg/mL (5.81 mM); Suspended solution; Need ultrasonic

Protocol 8

Add each solvent one by one: 5% DMSO 95% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (5.81 mM); Clear solution

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Protocole

Cell Assay^[1]

Normal human epidermal keratinocytes (NHEK) are grown in serum-free keratinocyte growth medium Epilife and used at third passage in all experiments. Growth supplement is omitted 48 h before experiments. As a control, IL-17A and IL-22 are either added or not added to the cells. Cultured NHEK cells are stimulated with IL-17A (200 ng/mL) and/or IL-22 (200 ng/mL) followed by co-incubation in the presence or absence of Calcipotriol at 0.2-40 nM to test its modulatory effect. Cells are harvested 3 days later and subjected to real-time quantitative PCR (qPCR). Culture supernatants are also collected and frozen at -80°C until use for ELISA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration^[3]

Mice^[3]
The 160 female SKH-1 hairless mice (6-7 weeks of age) are used. After UV treatment, mice without tumors are randomly divided into five groups, four chemoprevention groups (Diclofenac plus DFMO; Diclofenac plus Calcipotriol; DFMO plus calcitriol; and Diclofenac plus DFMO plus Calcipotriol) and one placebo group (skin lotion). The placebo group used in this study is the same as the one used in an earlier study. The mice are treated with test mixtures once a day, five days a week, for a total of 17 weeks. The test mixtures are applied topically on the dorsal surface of the mice. Ten microliters are applied by a pipette after which the mixture is rubbed onto the skin. This corresponded to the following doses of each active substance in the treatments: 100 μg/week for Diclofenac (30 mg/g undiluted), 0.166 μg/week for Calcitriol (50 μg/g undiluted), and 463.3 μg/week for difluoromethylornithine (DFMO) (139 mg/g undiluted).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (283 KB)
SDS (480 KB)
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- Portuguese - PT (480 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Al-Jaderi Z, et al. Effects of vitamin D3, calcipotriol and FTY720 on the expression of surface molecules and cytolytic activities of human natural killer cells and dendritic cells. Toxins (Basel). 2013 Oct 28;5(11):1932-47. [Content Brief]

[2]. Sakabe JI, et al. Calcipotriol Increases hCAP18 mRNA Expression but Inhibits Extracellular LL37 Peptide Production in IL-17/IL-22-stimulated Normal Human Epidermal Keratinocytes. Acta Derm Venereol. 2014 Sep;94(5):512-6. [Content Brief]

[3]. Pommergaard HC, et al. Combination chemoprevention with diclofenac, calcipotriol and difluoromethylornithine inhibits development of non-melanoma skin cancer in mice. Anticancer Res. 2013 Aug;33(8):3033-9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
Ethanol / DMSO	1 mM	2.3222 mL	11.6112 mL	23.2223 mL	58.0558 mL
	5 mM	0.4644 mL	2.3222 mL	4.6445 mL	11.6112 mL
	10 mM	0.2322 mL	1.1611 mL	2.3222 mL	5.8056 mL
	15 mM	0.1548 mL	0.7741 mL	1.5482 mL	3.8704 mL
	20 mM	0.1161 mL	0.5806 mL	1.1611 mL	2.9028 mL
	25 mM	0.0929 mL	0.4644 mL	0.9289 mL	2.3222 mL
	30 mM	0.0774 mL	0.3870 mL	0.7741 mL	1.9352 mL
	40 mM	0.0581 mL	0.2903 mL	0.5806 mL	1.4514 mL
	50 mM	0.0464 mL	0.2322 mL	0.4644 mL	1.1611 mL
	60 mM	0.0387 mL	0.1935 mL	0.3870 mL	0.9676 mL
	80 mM	0.0290 mL	0.1451 mL	0.2903 mL	0.7257 mL
	100 mM	0.0232 mL	0.1161 mL	0.2322 mL	0.5806 mL

Keywords

Calcipotriol monohydrate

49 Cited Publications

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Calcipotriol monohydrate

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Publications Citing Use of MedChemExpress (MCE) Calcipotriol monohydrate

Activité biologique

Chemical Information

Publications (49)

Solvant et solubilité

Protocole

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Calcipotriol monohydrate

Immunology/Inflammation Compound Library

FDA-Approved Drug Library

Anti-Cancer Compound Library

Drug Repurposing Compound Library

FDA Approved & Pharmacopeial Drug Library

Transcription Factor-Targeted Library

Rare Diseases Drug Library

FDA-Approved Anticancer Drug Library

Human Metabolite Library

Nuclear Receptor Compound Library

Osteogenesis Compound Library

Off-patent Drug Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Publications Citing Use of MedChemExpress (MCE) Calcipotriol monohydrate

Activité biologique

Chemical Information

Publications (49)

Solvant et solubilité

Protocole

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Calcipotriol monohydrate Related Classifications

HY-10001A Related Classifications