Sucralfate
Based on 1 Customer Validation
Sucralfate (Sucrose octasulfate-aluminum complex) is a potent and orally active gastroprotectant with no systemic effects. Sucralfate inhibits peptic activity and binds to negatively charged subepithelial proteins exposed during mucosal injury, forming a viscous layer that protects the vascular bed and proliferative zone. Sucralfate is used for prevention and research of several gastrointestinal diseases in vivo.
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- CAS No.: 54182-58-0
- Formule: C12H14Al16O75S8
- Masse moléculaire:2046.42
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Essai clinique
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 54182-58-0
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Appearance Solid
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Masse moléculaire 2046.42
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Formule C12H14Al16O75S8
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Color White to off-white
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SMILES
[OSO3[Al2(OH5)]][C@H]([C@@H](C[OSO3[Al2(OH5)]])O1)[C@H](O[S]=O=O=O=[OH5]#[Al]#[Al])[C@]1(C[OSO3[Al2(OH5)]])O[C@@H]2[C@H](O[S]=O=O=O=[OH5]#[Al]#[Al])[C@H](O[S]=O=O=O=[OH5]#[Al]#[Al])[C@H](O[S]=O=O=O=[OH5]#[Al]#[Al])[C@@H](C[OSO3[Al2(OH5)]])O2
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Synonyms
Sucrose octasulfate-aluminum complex
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvant et solubilité
In Vitro:
1 M HCl : 25 mg/mL (12.22 mM; Need ultrasonic)
1M NaOH : 20 mg/mL (9.77 mM; ultrasonic and adjust pH to 12 with 1M NaOH)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (282 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Chaim FM, et al. Evaluation of the application of enemas containing sucralfate in tissue content of neutral and acid mucins in experimental model of diversion colitis. Acta Cir Bras. 2014 Sep;29(9):544-52. [Content Brief]
[2]. Tracy L Hill, et al. Effect of sucralfate on gastric permeability in an ex vivo model of stress-related mucosal disease in dogs. J Vet Intern Med. 2018 Mar;32(2):670-678. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| 1M NaOH / 1 M HCl | 1 mM | 0.4887 mL | 2.4433 mL | 4.8866 mL | 12.2165 mL |
| 5 mM | 0.0977 mL | 0.4887 mL | 0.9773 mL | 2.4433 mL | |
| 1 M HCl | 10 mM | 0.0489 mL | 0.2443 mL | 0.4887 mL | 1.2216 mL |
Sucralfate Related Classifications
HY-B0644 Related Classifications
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