PI4P5K
Phosphatidylinositol 4-phosphate 5-kinases
Phosphatidylinositol 4-phosphate 5-kinases (PI4P5K) are a class of enzymes that phosphorylate phosphatidylinositol 4-phosphate. Phosphatidylinositol 4-phosphate 5-kinases phosphorylate phosphatidylinositol 4-phosphate (PI4P) in the 5-position to form phosphatidylinositol 4,5-bisphosphate (PI45P2). There are two types of phosphatidylinositol 4-phosphate 5-kinases found which includes Type I and Type II. Murine PI4P5K type Ibeta (mPIP5K-Ibeta) was implicated in receptor mediated endocytosis through the isolation of a truncated and inactive form of the enzyme that blocked the ligand-dependent downregulation of the colony-stimulating factor-1 receptor. Phosphatidylinositol 4-phosphate 5-kinases regulate diverse cellular processes such as G protein-coupled receptor(GPCR) signaling, vesicle trafficking, chemotaxis and cellular movement[1][2].
Références:
- [1]. Jones DH, et al. Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the golgi compartment. J Biol Chem. 2000 May 5;275(18):13962-6. [Content Brief]
- [2]. Galiano FJ, et al. Overexpression of murine phosphatidylinositol 4-phosphate 5-kinase type Ibeta disrupts a phosphatidylinositol 4,5 bisphosphate regulated endosomal pathway. J Cell Biochem. 2002;85(1):131-45. [Content Brief]
All Product Categories
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PI4P5K Produits associés (7)
Produits associés (7)
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ISA-2011B
0 ImagesISA-2011B is a PIP5K1α inhibitor with promising anticancer effects .
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UNC3230
0 ImagesUNC3230 is a potent, selective and ATP-competitive PIP5K1C inhibitor with an IC50 of ~41 nM. UNC3230 also inhibits PIP4K2C and does not inhibit any of the other lipid kinases that regulate phosphoinositide levels. UNC3230 has antinociceptive and anticancer effects.
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PIP5K1α-IN-1
0 ImagesPIP5K1α-IN-1 (Compound 3e) is an inhibitor for phosphatidylinositol 4-phosphate 5-kinase type I α (PIP5K1α) with an IC50 of 0.46 μM.
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PIP5K1C-IN-2
0 ImagesCat. No.: HY-163477CAS No.: 3060954-34-6PIP5K1C-IN-2 (compound 33) is a potent and selective 4-phosphate 5-kinases 1 C (PIP5K1C) inhibitor with an IC50 value of 0.0059 µM.
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1,2-Dilinoleoyl phosphatidylinositol
0 ImagesCat. No.: HY-N19037CAS No.: 182509-36-01,2-Dilinoleoyl phosphatidylinositol is a phosphatidylinositol. 1,2-Dilinoleoyl phosphatidylinositol acts as a substrate for phosphorylation by Phosphatidylinositol-4-phosphate 5-kinase (PI4P5K) isoforms α, β, and γ in in vitro assays.
