Antifibrotic agent 3
Antifibrotic agent 3 is an orally active antifibrotic agent. Antifibrotic agent 3 reduces hepatic stellate cell activation by downregulating the expression of Collagen I and α-SMA. Antifibrotic agent 3 inhibits liver fibrosis in bile duct ligation and carbon tetrachloride-induced liver fibrosis models. Antifibrotic agent 3 can be used for the research of liver fibrosis.
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- CAS No.: 2103516-38-5
- Formule: C13H13FN2O2
- Masse moléculaire:248.25
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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Collagen I |
Antifibrotic agent 3 (10 mg/kg; p.o.; once daily; for 14 consecutive days) reduces CCl4-induced liver injury, collagen deposition, and expression of hepatic fibrosis markers in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male, 6-7 weeks old, 20-22 g, BDL-induced)[1]
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Dosage:10 mg/kg
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Administration:p.o.; daily; 14 days
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Result:Reduced elevated serum ALT, AST, and AKP levels.
Alleviated liver hardening, rough surface, and yellowish spots.
Reduced inflammatory cell infiltration, hepatocyte edema, and necrosis.
Decreased collagen fiber accumulation.
Lowered hepatic hydroxyproline (HYP) levels.
Reduced liver tissue expression of α-SMA and Collagen I.
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Animal Model:C57BL/6J (male, 6-7 weeks old, 20-22 g, CCl4-induced)[1]
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Dosage:10 mg/kg
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Administration:p.o.; daily; 14 days
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Result:Reduced elevated serum ALT and AST levels.
Reduced liver granularity and increased liver glossiness.
Alleviated cellular swelling and inflammatory cell infiltration.
Decreased collagen fiber-stained area.
Lowered hepatic hydroxyproline (HYP) levels.
Reduced liver tissue expression of α-SMA and Collagen I.
Chemical Information
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CAS No. 2103516-38-5
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Masse moléculaire 248.25
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Formule C13H13FN2O2
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SMILES
COC(C1NCCC2=C1NC3=CC(F)=CC=C32)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antifibrotic agent 3 Related Classifications
HY-184738 Related Classifications
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