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Cat. No.: HY-189531

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Antioxidant agent-26

Antioxidant agent-26 is a DPPH free radical scavenger. Antioxidant agent-26 has broad-spectrum ultraviolet absorption properties and iron-reducing ability. Antioxidant agent-26 blocks the hERG potassium channel and reduces the tail current. Antioxidant agent-26 inhibits the proliferation of dermatophytes and tumor cells. Antioxidant agent-26 can be used in research related to T-cell leukemia, melanoma, and dermatophytosis.

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CAS No.: 24978-47-0
Formule: C₁₃H₉NO₂S
Masse moléculaire:243.28

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Please store the product under the recommended conditions in the Certificate of Analysis.

Antioxidant agent-26 Chemical Structure

CAS No.: 24978-47-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Protocole (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC50	2.0 μM	Antiproliferative activity against human CEM T-cell leukemia cells assessed as IC50 by Coulter counter after 48 or 72 hrs incubation. Antiproliferative activity against human CEM T-cell leukemia cells assessed as IC50 by Coulter counter after 48 or 72 hrs incubation.	32559579
HeLa	IC50	74 μM	Antiproliferative activity against human HeLa cervix carcinoma cells assessed as IC50 by Coulter counter after 4 days incubation. Antiproliferative activity against human HeLa cervix carcinoma cells assessed as IC50 by Coulter counter after 4 days incubation.	32559579
MIA PaCa-2	IC50	38 μM	Antiproliferative activity against human Mia-Paca-2 pancreas carcinoma cells assessed as IC50 by Coulter counter after 4 days incubation. Antiproliferative activity against human Mia-Paca-2 pancreas carcinoma cells assessed as IC50 by Coulter counter after 4 days incubation.	32559579
SK-MEL-5	IC50	5.3 μM	Antiproliferative activity against human SK-Mel 5 melanoma cells assessed as IC50 by Coulter counter. Antiproliferative activity against human SK-Mel 5 melanoma cells assessed as IC50 by Coulter counter.	32559579
HEK293	IC50	13 μM	Cytotoxicity against normal human HEK 293 kidney epithelial cells assessed as IC50 by Coulter counter. Cytotoxicity against normal human HEK 293 kidney epithelial cells assessed as IC50 by Coulter counter.	32559579

In Vitro

Antioxidant agent-26 (compound 4g) (0.0625-1 mg/mL; 30 min) scavenges DPPH radicals with an IC₅₀ of 6.42 µg/mL, an inhibition rate of 94.32% at high concentration, and a FRAP value of 6268.43 µmolT/g^[1].
Antioxidant agent-26 (100 µg/mL; 7 days) exhibited significant anti-dermatophyte activity against M. gypseum and E. floccosum^[1].
Antioxidant agent-26 (100 µM; 2-4 days) exhibits the strongest activity against CEM and SK-Mel 5 cells, with IC₅₀ values of 2.0 µM and 5.3 µM, respectively^[1].
Antioxidant agent-26 (0.1-10 µM; 5 min) blocks hERG potassium channels expressed in HEK293 cells with an IC₅₀ of 4.79 µM and an inhibition rate of 60.32% at high concentrations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 24978-47-0
Masse moléculaire 243.28
Formule C₁₃H₉NO₂S
SMILES

OC1=CC=C(C(C2=NC3=C(S2)C=CC=C3)=C1)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology

Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Djuidje EN, et al. Design, synthesis and evaluation of benzothiazole derivatives as multifunctional agents. Bioorganic chemistry. 2020 Aug;101:103960.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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