Antitumor agent-204
Antitumor agent-204 (compound 15a) is a potent antitumor agent. Antitumor agent-204 shows cytotoxicity. Antitumor agent-204 induces nitric oxide (NO) release and reactive oxygen species (ROS) generation. Antitumor agent-204 induces apoptosis and induces cell cycle arrest at G2/M phase. Antitumor agent-204 shows antitumor activity.
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- Formule: C39H33N3O8S
- Masse moléculaire:703.76
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Antitumor agent-204 (compound 15a) (0-10 μM; 48 h) shows cytotosicity for A549, A549/Taxol MDA-MB-231, MCF-7, BEAS-2B, HUVEC cells with IC50s of 4.43, 0.87, 1.20, 5.54, 10.73, 13.25 μM, respectively[1].
Antitumor agent-204 (1, 2.5, 5 μM; 24 h) induces cell apoptosis in a dose-dependentmanner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549, A549/Taxol, MDA-MB-231, MCF-7, BEAS-2B, HUVEC cells
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Concentration:0-10 μM
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Incubation Time:48 h
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Result:Showed cytotoxicity for A549, A549/Taxol MDA-MB-231, MCF-7, BEAS-2B, HUVEC cells with IC50s of 4.43, 0.87, 1.20, 5.54, 10.73, 13.25 μM, respectively.
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Cell Line:A549/Taxol cells
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Concentration:1, 2.5, 5 μM
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Incubation Time:24 h
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Result:Induced cell apoptosis in a dose-dependentmanner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/c nude mice (A549/Taxol cells)[1]
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Dosage:1, 5, 10 mg/kg
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Administration:IP; Once every 4 days for 16 days
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Result:Showed antitumor activity by significantly inhibited tumor growth by 50.2 %, 61.2 %, and 72.3 % (w/w) at 1, 5, and 10 mg/kg, respectively.
Chemical Information
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Masse moléculaire 703.76
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Formule C39H33N3O8S
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SMILES
CN1CCOC2=C3OC4=C1C=CC(CCC5=CC=C(C(OC6=CC=C(CCC3=CC=C2)C=C6)=C5)OC7=NO[N+]([O-])=C7S(=O)(C8=CC=CC=C8)=O)=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-204 Related Classifications
HY-176738 Related Classifications
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