Apoptosis inducer 17
Apoptosis inducer 17 is a Curcumin-Piperlongumine hybrid molecule that increases cell cycle arrest and apoptosis through activating JNK signaling pathway in lung cancer cells.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 3126845-21-1
- Formule: C25H27NO7
- Masse moléculaire:453.48
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Protocole
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
In Vitro
Apoptosis inducer 17 (compound CP; 0.027-60 μM; 72 h) inhibits cell proliferation, with IC50 values of 0.021 μM, 0.027 μM, and 0.73 μM for H446, H1299, and SBC-2 cells, respectively[1].
Apoptosis inducer 17 (compound CP; 0.03-0.3 μM; 24 h) displays superior inhibition of colony formation. Apoptosis inducer 17 induces dose-dependent G2/M arrest in H446 and H1299 cells[1].
Apoptosis inducer 17 (compound CP; 0.03-0.3 μM; 24 h) induces apoptosis of H446 and H1299 cells is mediated by caspase activity. And also activates JNK signaling cascade[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:H446, H1299, and SBC-2 cells
-
Concentration:60 μM, 20 μM, 6.67 μM, 2.22 μM, 0.74 μM, 0.25 μM, 0.082 μM, and 0.027 μM
-
Incubation Time:72 h
-
Result:Effectively inhibited cell proliferation.
-
Cell Line:H446, H1299 cells
-
Concentration:0.03 μM, 0.1 μM, 0.3 μM
-
Incubation Time:24 h
-
Result:Induced dose-dependent G2/M arrest.
-
Cell Line:H446, H1299 cells
-
Concentration:0.03 μM, 0.1 μM, 0.3 μM
-
Incubation Time:24 h
-
Result:Induced apoptosis of H446 and H1299 cells.
-
Cell Line:H446, H1299 cells
-
Concentration:0.03 μM, 0.1 μM, 0.3 μM
-
Incubation Time:24 h
-
Result:Led to a dose-dependent increase in the phosphorylation of JNK, c-Jun and activating transcription factor-2 (ATF-2) in both H446 and H1299 cells.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:BALB/c nude mice (4-6 weeks old) injected with H446 cells[1]
-
Dosage:10 mg/kg
-
Administration:ip; twice a day; for 15 days
-
Result:Prevented growth of lung cancer in xenograft tumors.
Chemical Information
-
CAS No. 3126845-21-1
-
Masse moléculaire 453.48
-
Formule C25H27NO7
-
SMILES
O=C1N(C(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)=O)CCC/C1=C\C3=CC=C(O)C(OC)=C3
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apoptosis inducer 17 Related Classifications
HY-163451 Related Classifications
Powered by Bioz