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Cat. No.: HY-P5811

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Ceratotoxin-1

Name: Ceratotoxin-1
Brand: MedChemExpress
SKU: HY-P5811
Availability: PreOrder

(Synonyms: CcoTx1; β-TRTX-cm1a)

Ceratotoxin-1 (CcoTx1), a peptide toxin, is an voltage-gated sodium channel subtypes inhibitor. Ceratotoxin-1 inhibits Nav1.1/β1, Nav1.2/β1, Nav1.4/β1, and Nav1.5/β1 with IC₅₀ of 523 nM, 3 nM, 888 nM, and 323 nM, respectively. Ceratotoxin-1 also inhibits Nav1.8/β1.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₁₇₂H₂₅₆N₅₂O₅₀S₆

Masse moléculaire:4044.58

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (260 KB)

Synthèse personnalisée de peptides

Ceratotoxin-1 Chemical Structure

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This compound is listed in the SVHC (Substances of Very High Concern) candidate list of ECHA (European Chemicals Agency).

Data Download

Data Sheet (260 KB)

Instruction de manipulation (2659 KB)

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Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec

Activité biologique

Chemical Information

Protocole

Pureté et documentation

Références

Help & FAQs

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Voir tous les produits spécifiques à Isoform Sodium Channel
More

Na_v1.1

Na_v1.2

Na_v1.3

Na_v1.4

Na_v1.5

Na_v1.6

Na_v1.7

Na_v1.8

Na_v1.9

Activité biologique

Description

IC₅₀ & Target

Chemical Information

Protocole (1)

Pureté et documentation

Références

Calculators

Help & FAQs

Classifications

Bioz

Activité biologique

Description

Ceratotoxin-1 (CcoTx1), a peptide toxin, is an voltage-gated sodium channel subtypes inhibitor. Ceratotoxin-1 inhibits Nav1.1/β1, Nav1.2/β1, Nav1.4/β1, and Nav1.5/β1 with IC₅₀ of 523 nM, 3 nM, 888 nM, and 323 nM, respectively. Ceratotoxin-1 also inhibits Nav1.8/β1^[1].

IC₅₀ & Target
^[1]

Nav1.1

523 nM (IC₅₀)

Nav1.2

3 nM (IC₅₀)

Nav1.4

888 nM (IC₅₀)

Nav1.5

323 nM (IC₅₀)

Nav1.8

Voir tous les produits spécifiques à Isoform Sodium Channel :

Na_v1.1

Na_v1.2

Na_v1.3

Na_v1.4

Na_v1.5

Na_v1.6

Na_v1.7

Na_v1.8

Na_v1.9

Chemical Information

Masse moléculaire 4044.58

Formule C₁₇₂H₂₅₆N₅₂O₅₀S₆

Synonyms

CcoTx1; β-TRTX-cm1a

Sequence

Asp-Cys-Leu-Gly-Trp-Phe-Lys-Ser-Cys-Asp-Pro-Lys-Asn-Asp-Lys-Cys-Cys-Lys-Asn-Tyr-Thr-Cys-Ser-Arg-Arg-Asp-Arg-Trp-Cys-Lys-Tyr-Asp-Leu-NH2 (Disulfide bridge:Cys2-Cys17;Cys9-Cys22;Cys16-Cys29)

Sequence Shortening

DCLGWFKSCDPKNDKCCKNYTCSRRDRWCKYDL-NH2 (Disulfide bridge:Cys2-Cys17;Cys9-Cys22;Cys16-Cys29)

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology
More

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (260 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Frank Bosmans, et al. Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes. Mol Pharmacol. 2006 Feb;69(2):419-29. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

=
Concentration Concentration

×
Volume Volume

×
Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

×

Volume _(start) Volume _(start)

=

Concentration _(final) Concentration _(final)

×

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Ceratotoxin-1 Related Classifications

HY-P5811 Related Classifications

Membrane Transporter/Ion Channel

Sodium Channel

Aires thérapeutique

Neurological, Eye or Ear Disease

Peptides

Peptide and Derivatives

Inhibitors and Substrates

Ion Channel Modulators

Neurological Disease

Bioz

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Keywords

Ceratotoxin-1
CcoTx1
β-TRTX-cm1a
Ceratotoxin1
Ceratotoxin 1
CcoTx 1
CcoTx-1
Sodium Channel
peptide toxin
Nav1.1/β
Nav1.2/β
Nav1.4/β
Nav1.5/β
and Nav1.8/β
Inhibitor
inhibitor
inhibit

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ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社

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Ceratotoxin-1

Voir tous les produits spécifiques à Isoform Sodium Channel

Activité biologique

Description

IC50 & Target

Chemical Information

Protocole

Pureté et documentation

Références

Calculators

Help & FAQs

Ceratotoxin-1 Related Classifications

HY-P5811 Related Classifications

Bioz

Keywords

Your Recently Viewed Products

IC₅₀ & Target