Dimethyl sulfoxide
(Synonyms: DMSO)
53 Cited Publications
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Based on 53 publication(s) in Google Scholar
Dimethyl sulfoxide (DMSO) is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity.
Low endotoxin, can be used in various biochemical experiments such as drug dissolution.
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- Pureté: 99.98%
- CAS No.: 67-68-5
- Formule: C2H6OS
- Masse moléculaire:78.13
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Dimethyl sulfoxide
More- Autophagy. 2026 Jun 21:1-25. [Abstract]
- Adv Sci (Weinh). 2026 Jun;13(34):e16332. [Abstract]
- Adv Sci (Weinh). 2026 May;13(25):e15933. [Abstract]
- Engineering. 2025 Nov 14.
- Phytomedicine. 2026 Mar:152:157826. [Abstract]
- Acta Biomater. 2026 Jul:218:244-260. [Abstract]
- Acta Pharmacol Sin. 2026 May 25. [Abstract]
- Cell Death Discov. 2025 Nov 7;11(1):511. [Abstract]
- J Transl Med. 2026 May 22. [Abstract]
- J Transl Med. 2025 Nov 12;23(1):1271. [Abstract]
- Cell Chem Biol. 2026 Mar 19;33(3):307-320.e4. [Abstract]
- Antioxidants (Basel). 2026 May 18;15(5):639. [Abstract]
- Phytother Res. 2026 Jun;40(6):3595-3612. [Abstract]
- Am J Chin Med. 2026;54(4):1281-1307. [Abstract]
- Br J Cancer. 2025 Sep;133(5):697-708. [Abstract]
- J Agric Food Res. 2025 Oct 27;24:102486.
- Antioxid Redox Signal. 2025 Dec 26. [Abstract]
- CNS Neurosci Ther. 2026 Feb;32(2):e70777. [Abstract]
- CNS Neurosci Ther. 2025 Dec;31(12):e70661. [Abstract]
- Biochem Pharmacol. 2026 Sep;251(Pt 1):118089. [Abstract]
- Biochem Pharmacol. 2026 May:247:117796. [Abstract]
- Biochem Pharmacol. 2026 Apr:246:117708. [Abstract]
- Cancer Biol Ther. 2026 Dec 31;27(1):2665867. [Abstract]
- Eur J Pharmacol. 2026 Jun 3:1030:179053. [Abstract]
- Int Immunopharmacol. 2026 May 14:182:116841. [Abstract]
- Int Immunopharmacol. 2025 Jun 5:157:114764. [Abstract]
- Microchem J. 2025 Nov 3;219:116046.
- Chem Biol Interact. 2025 Sep 20:111749. [Abstract]
- Sci Rep. 2026 Apr 18;16(1):17992. [Abstract]
- Sci Rep. 2025 Dec 11. [Abstract]
- Cell Signal. 2026 Sep:145:112578. [Abstract]
- Mol Cell Biochem. 2025 Jun 11. [Abstract]
- Oncol Res. 2026 Jan 19;34(2):25. [Abstract]
- Biomedicines. 2026 Mar 30;14(4):781. [Abstract]
- iScience. 2025 Nov 21;28(12):114175. [Abstract]
- Brain Res Bull. 2025 Aug 24:230:111523. [Abstract]
- Comp Biochem Physiol C Toxicol Pharmacol. 2026 Jul:305:110517. [Abstract]
- Antimicrob Agents Chemother. 2025 May 7;69(5):e0189224. [Abstract]
- Front Biosci (Landmark Ed). 2025 Jun 25;30(6):37052. [Abstract]
- Curr Issues Mol Biol. 2025 May 14;47(5):361. [Abstract]
- Naunyn Schmiedebergs Arch Pharmacol. 2026 Jan 28. [Abstract]
- J Hepatocell Carcinoma. 2025 Dec 24:12:2971-2988. [Abstract]
- Ren Fail. 2026 Dec;48(1):2667591. [Abstract]
- Toxicol Appl Pharmacol. 2026 Aug:513:117836. [Abstract]
- J Integr Neurosci. 2025 Aug 22;24(8):39286. [Abstract]
- J Integr Neurosci. 2025 Aug 21;24(8):39532. [Abstract]
- Acta Diabetol. 2025 May 12. [Abstract]
- Vet Microbiol. 2026 Feb:313:110871. [Abstract]
- Biochem Biophys Res Commun. 2026 Mar 12:804:153353. [Abstract]
- Oncol Lett. 2026 Apr 20;31(6):254. [Abstract]
- SSRN. 2026 Mar 19.
- Res Sq. 2026 Feb 10.
- bioRxiv. 2025 Sep 21.
Activité biologique
Description
Dimethyl sulfoxide (DMSO) is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity[1].
Low endotoxin, can be used in various biochemical experiments such as drug dissolution.
Low endotoxin, can be used in various biochemical experiments such as drug dissolution.
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Erythroleukemia cell line | IC50 |
280 mM
Compound: DMSO
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Anticancer activity against mouse Erythroleukemia cell line assessed as inhibition of cell growth
Anticancer activity against mouse Erythroleukemia cell line assessed as inhibition of cell growth
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[PMID: 34591474] |
| HEK293 | IC50 |
232 μM
Compound: DMSO
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Antiproliferative activity against HEK293 cells after 48 hrs by MTT assay
Antiproliferative activity against HEK293 cells after 48 hrs by MTT assay
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[PMID: 27108400] |
| HL-60 | IC50 |
108 μM
Compound: DMSO
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Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
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[PMID: 27108400] |
| LN-18 | IC50 |
223 μM
Compound: DMSO
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Antiproliferative activity against human LN18 cells after 48 hrs by MTT assay
Antiproliferative activity against human LN18 cells after 48 hrs by MTT assay
|
[PMID: 27108400] |
| MDCK-II | GI50 |
123 μM
Compound: DMSO
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Growth inhibition of MDCK2 cells after 72 hrs by MTT assay
Growth inhibition of MDCK2 cells after 72 hrs by MTT assay
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[PMID: 32787102] |
| MDCK-II | GI50 |
137 μM
Compound: DMSO
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Growth inhibition of MDCK2 cells over expressing human ABCG2 after 72 hrs by MTT assay
Growth inhibition of MDCK2 cells over expressing human ABCG2 after 72 hrs by MTT assay
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[PMID: 32787102] |
| THP-1 | IC50 |
119 μM
Compound: DMSO
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Antiproliferative activity against human THP1 cells after 48 hrs by MTT assay
Antiproliferative activity against human THP1 cells after 48 hrs by MTT assay
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[PMID: 27108400] |
In Vitro
Dimethyl sulfoxide (DMSO) is a colorless liquid. Dimethyl sulfoxide is a polar, aprotic solvent miscible with water and able to dissolve an enormous catalog of polar and nonpolar small molecules.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Essai clinique
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 67-68-5
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Appearance Liquid (Density: 1.1 g/cm3)
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Masse moléculaire 78.13
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Formule C2H6OS
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Color Colorless to light yellow
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SMILES
O=S(C)C
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Synonyms
DMSO
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (53)
All
Journal Impact Factor
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Journal Impact Factor
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Most Recent
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Autophagy
E-cigarette aerosols induce the hydrolysis of lysosomal glycerophospholipids through PLA2G4A activation initiated by nicotine binding to CHRNA3/α3 nAChR in airway epithelial cells. [Abstract]2026 Jun 21:1-25. PMID: 42287088 -
Adv Sci (Weinh)
Causal Prediction of TP53 Variant Pathogenicity Using a Perturbation-Informed Protein Language Model. [Abstract]2026 Jun;13(34):e16332. PMID: 41955512 -
Adv Sci (Weinh)
Activated Platelet-Released Heat Shock Protein 90α Triggers Autophagy-Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis. [Abstract]2026 May;13(25):e15933. PMID: 41732887 -
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Phytomedicine
From virtual screening to functional discovery: Apigenin ameliorates acute pancreatitis by targeting HINT2 to regulate the mitochondrial acetylome. [Abstract]2026 Mar:152:157826. PMID: 41579589 -
Acta Biomater
Mechanically heterogeneous nanofibrous hydrogel drives Piezo1-mediated cell aggregation and collective migration. [Abstract]2026 Jul:218:244-260. PMID: 42270027 -
Acta Pharmacol Sin
Sirolimus potentiates oncolytic Virus M1 efficacy through tumor-selective augmentation of viral replication. [Abstract]2026 May 25. PMID: 42178397 -
Cell Death Discov
Pregnane X receptor protects against age-related bone loss in males via PI3K/Akt-mediated inhibition of apoptosis. [Abstract]2025 Nov 7;11(1):511. PMID: 41203627 -
J Transl Med
Targeting C5AR1 disrupts complement-driven G0-phase maintenance and overcomes metabolic drug resistance in glioma. [Abstract]2026 May 22. PMID: 42174621 -
J Transl Med
Retinal ALKBH5 inhibition induces myopia protection through selective regulation of ERK1/2 signaling. [Abstract]2025 Nov 12;23(1):1271. PMID: 41225555 -
Cell Chem Biol
2026 Mar 19;33(3):307-320.e4. PMID: 41650963 -
Antioxidants (Basel)
Rhamnocitrin Ameliorates the Intestinal Fibrosis in DSS-Induced Colitis Mice by Modulating Host-Metabolites and Remodeling the Gut Microbiome. [Abstract]2026 May 18;15(5):639. PMID: 42193259 -
Phytother Res
Hesperidin Promotes Peripheral Nerve Repair by Inducing Autophagy and Inhibiting Apoptosis via the STAT3/Bcl-2 Pathway. [Abstract]2026 Jun;40(6):3595-3612. PMID: 41945422 -
Am J Chin Med
Astragaloside IV Ameliorates Diabetic Kidney Disease via Inhibiting MAPK Pathway and Alleviating Metabolic Dysregulation. [Abstract]2026;54(4):1281-1307. PMID: 42289390 -
Br J Cancer
New mechanistic understanding of FXR agonist Vonafexor: inducing sublethal damage of HBV-positive liver cancer cells via promoting anti-tumor immunity. [Abstract]2025 Sep;133(5):697-708. PMID: 40588513 -
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Antioxid Redox Signal
Hydrogen Attenuates Oxidative Damage via NRF2-Mediated Mitophagy after Subarachnoid Hemorrhage. [Abstract]2025 Dec 26. PMID: 41468154 -
CNS Neurosci Ther
TREM2 Facilitates Myelin Debris Clearance but Exacerbates Chronic Inflammation and Fibrosis After Spinal Cord Injury. [Abstract]2026 Feb;32(2):e70777. PMID: 41660680 -
CNS Neurosci Ther
Mechanism of Hypoxia-Induced HMGB1 Regulating NLRP3 Inflammasome/Caspase-1 Pathway-Mediated Pyroptosis in Myocardial Ischemia Reperfusion Injury Through the Nrf2/HO-1 Pathway. [Abstract]2025 Dec;31(12):e70661. PMID: 41378869 -
Biochem Pharmacol
Calcitriol protects against diabetic kidney disease by alleviating ferroptosis in renal tubular epithelial cells via JUN/ATF3 pathway. [Abstract]2026 Sep;251(Pt 1):118089. PMID: 42167448 -
Biochem Pharmacol
Mutant NPM1-regulated estrogen signaling promotes leukemia cell survival by upregulating HGF and represents a therapeutic vulnerability. [Abstract]2026 May:247:117796. PMID: 41679667 -
Biochem Pharmacol
Arachidonic acid analog AACOCF3 suppresses cPLA2-negative NSCLC cell proliferation by targeting SSRP1 to activate the IFNα/β pathway. [Abstract]2026 Apr:246:117708. PMID: 41544858 -
Cancer Biol Ther
Inhibition of STAT3-mediated glycolysis by bruceine D suppresses non-small-cell lung cancer progression in vitro and in vivo. [Abstract]2026 Dec 31;27(1):2665867. PMID: 42100892 -
Eur J Pharmacol
Capsaicin attenuates DSS-induced IBD by suppressing macrophage M1 polarization via inhibition of the TRAF1/NF-κB pathway. [Abstract]2026 Jun 3:1030:179053. PMID: 42242492 -
Int Immunopharmacol
Albiflorin contributes to Xuebijing-mediated protection against sepsis-associated acute kidney injury by modulating the succinate-PFKFB3 immunometabolic axis. [Abstract]2026 May 14:182:116841. PMID: 42134292 -
Int Immunopharmacol
Andrographolide attenuates PM2.5-induced blood-brain barrier damage via antioxidant and PI3K/AKT/mTOR/NRF2 pathways. [Abstract]2025 Jun 5:157:114764. PMID: 40339493 -
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Chem Biol Interact
Phytosphingosine suppresses gastric cancer through SFRP4/β-catenin axis-mediated Wnt signaling pathway inhibition. [Abstract]2025 Sep 20:111749. PMID: 40983245 -
Sci Rep
m6A demethylase FTO promotes the progression of abdominal aortic aneurysm through PDK4-mediated apoptosis. [Abstract]2026 Apr 18;16(1):17992. PMID: 42000779 -
Sci Rep
Cirsiliol alleviates diabetic cardiomyopathy by inhibiting oxidative stress and improving energy metabolism through the PPAR-α/AMPK pathway. [Abstract]2025 Dec 11. PMID: 41381837 -
Cell Signal
HO-1 enhances autophagy to alleviate oxidative damage in BMECs via Keap1/Nrf2 and AMPK/mTOR signaling. [Abstract]2026 Sep:145:112578. PMID: 42105892 -
Mol Cell Biochem
FOXM1 upregulation, promotes immune escape in gastric cancer through activation of Notch signaling pathway. [Abstract]2025 Jun 11. PMID: 40498401 -
Oncol Res
SDHA Deficiency in Hepatocellular Carcinoma Promotes Tumor Progression through Succinate-Induced M2 Macrophage Polarization. [Abstract]2026 Jan 19;34(2):25. PMID: 41613800 -
Biomedicines
Chrysin Pretreatment Enhances BMSC Therapeutic Efficacy in Resolving Diabetic Wound Healing. [Abstract]2026 Mar 30;14(4):781. PMID: 42072322 -
iScience
A translational study on the survival and molecular mechanism of PD-L1 expression in EGFR-mutant NSCLC treated with osimertinib. [Abstract]2025 Nov 21;28(12):114175. PMID: 41446744 -
Brain Res Bull
Dexmedetomidine attenuates postoperative delirium by activating Nrf2 to reduce oxidative stress and blood-brain barrier disruption. [Abstract]2025 Aug 24:230:111523. PMID: 40858194 -
Comp Biochem Physiol C Toxicol Pharmacol
Inactivation of the AMPKα/CncC/GPX4 axis mediates rotenone-induced ferroptosis in the silkworm (Bombyx mori) model. [Abstract]2026 Jul:305:110517. PMID: 41887387 -
Antimicrob Agents Chemother
Impact of hepatic impairment and renal failure on the pharmacokinetics of linezolid and its metabolites: contribution of hepatic metabolism and renal excretion. [Abstract]2025 May 7;69(5):e0189224. PMID: 40227039 -
Front Biosci (Landmark Ed)
2025 Jun 25;30(6):37052. PMID: 40613298 -
Curr Issues Mol Biol
2025 May 14;47(5):361. PMID: 40699760 -
Naunyn Schmiedebergs Arch Pharmacol
Network pharmacology and experimental validation to explore the effects and mechanisms of flavonoids luteolin and chrysoeriol against non‑small cell lung cancer. [Abstract]2026 Jan 28. PMID: 41603923 -
J Hepatocell Carcinoma
Integrated Transcriptomic Analysis Leveraging Single-Cell and Bulk RNA Sequencing Data to Uncover Pyroptosis-Related Prognostic Signatures in HCC. [Abstract]2025 Dec 24:12:2971-2988. PMID: 41467099 -
Ren Fail
Bufalin post-transcriptionally suppresses STAT3 to alleviate renal ferroptosis and tubulointerstitial fibrosis in diabetic kidney disease. [Abstract]2026 Dec;48(1):2667591. PMID: 42186424 -
Toxicol Appl Pharmacol
ADAMTS7 selective inhibitor BAY-9835 alleviates acute myocardial infarction by suppressing the NF-κB-mediated pyroptosis. [Abstract]2026 Aug:513:117836. PMID: 42061659 -
J Integr Neurosci
Inhibition of cGAS Reduces Brain Injury and Facilitates Neurological Recovery via the STING-Mediated Signaling Pathway After Germinal Matrix Hemorrhage in Neonatal Mice. [Abstract]2025 Aug 22;24(8):39286. PMID: 40919625 -
J Integr Neurosci
Glucocorticoid Alleviates Stress-induced Hypothalamic Nerve Injury by Inhibiting the GSDMD-dependent Pyroptosis Pathway. [Abstract]2025 Aug 21;24(8):39532. PMID: 40919628 -
Acta Diabetol
Dapagliflozin ameliorates metabolic and hepatic outcomes in a mouse model of metabolic dysfunction-associated steatotic liver disease and diabetes. [Abstract]2025 May 12. PMID: 40353918 -
Vet Microbiol
Phosphorylation of T425 and methylation of R426 synergistically regulate IBDV VP1 function and viral replication. [Abstract]2026 Feb:313:110871. PMID: 41506171 -
Biochem Biophys Res Commun
Erianin induces ferroptosis in ovarian cancer cells by upregulating PDP2 and activating the JNK signaling pathway. [Abstract]2026 Mar 12:804:153353. PMID: 41619504 -
Oncol Lett
METTL5 reprograms glycolytic metabolism and promotes non-small cell lung cancer progression by modifying PGAM1. [Abstract]2026 Apr 20;31(6):254. PMID: 42057886 -
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Pureté et documentation
Select Batch:
Pureté:
99.98%
Assay:
99.98%
ee.:
99.98%
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Fiche technique (275 KB)
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SDS (251 KB)
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- Français - FR (251 KB)
- Deutsch - DE (251 KB)
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- Español - ES (251 KB)
- Swedish - SV (251 KB)
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Instruction de manipulation (2659 KB)
Références
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Dimethyl sulfoxide Related Classifications
HY-Y0320C Related Classifications
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