country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-187400A

Copy Link Print Information

DOPE-PEG2000-YIGSR

(Synonyms: DOPE-PEG2000-Mal-Cys-YIGSR)

DOPE-PEG2000-YIGSR (DOPE-PEG2000-Mal-Cys-YIGSR) is an amphiphilic lipid-PEG-peptide conjugate consisting of DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine), PEG2000, and the YIGSR peptide (Tyr-Ile-Gly-Ser-Arg), a sequence derived from the beta-1 chain of laminin. YIGSR peptide binds to the 67 kDa laminin receptor that is overexpressed on various tumor cells. DOPE-PEG2000-YIGSR is used for tumor-targeted drug delivery and anti-metastatic research.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DOPE-PEG2000-YIGSR Chemical Structure

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

DOPE-PEG2000-YIGSR: surface modification of liposomes and nanoparticles for laminin receptor-targeted drug delivery to tumor cells, and for anti-metastatic therapy by blocking tumor cell adhesion and invasion.
Structural composition:
(1) DOPE; a fusogenic phospholipid with two unsaturated oleoyl chains that anchors into lipid membranes and promotes pH-responsive membrane fusion for endosomal escape;
(2) PEG2000; a hydrophilic polymer that creates a stealth layer reducing immune clearance and prolonging circulation half-life;
(3) YIGSR peptide; a pentapeptide derived from laminin beta-1 chain that specifically binds to the 67 kDa laminin receptor overexpressed on tumor cells, enabling active targeting while also competitively inhibiting tumor cell adhesion to basement membranes, thereby suppressing metastasis.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

SMILES

[DOPE-PEG2000-YIGSR]
Synonyms

DOPE-PEG2000-Mal-Cys-YIGSR
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.