FP1-24
FP1-24 is a non-selective CK1 kinase inhibitor, with IC50 values of 40 nM, 10 nM, 10 nM, and 40 nM against human CK1γ1, CK1γ2, CK1γ3 and CK1δ, respectively. FP1-24 exerts its activity by reducing the phosphorylation level of LRP5/6 at the T1479 site during WNT signaling pathway activation. The non-specific binding of FP1-24 to multiple kinases can be used for biological studies of specific CK1γ.
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- CAS No.: 1403557-08-3
- Formule: C20H17F2N3O3
- Masse moléculaire:385.36
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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CK1γ1 40 nM (IC50) |
CK1γ2 10 nM (IC50) |
CK1γ3 10 nM (IC50) |
CK1δ 40 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| HEK293 | IC50 |
0.2 μM
Compound: 13
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Inhibition of human CK1-gamma2 in HEK293 cells assessed as inhibition of doxcycline-induced LRP6 phosphorylation after 2 hrs by electrochemiluminescence analysis
Inhibition of human CK1-gamma2 in HEK293 cells assessed as inhibition of doxcycline-induced LRP6 phosphorylation after 2 hrs by electrochemiluminescence analysis
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[PMID: 24900428] |
FP1-24 (10 μM; 2 h) reduces LRP6 phosphorylation at T1479 in WNT-activated HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1403557-08-3
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Masse moléculaire 385.36
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Formule C20H17F2N3O3
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SMILES
COC1=CN=C(COC2=CC=C(F)C(F)=C2)C=C1C(N3)=CC4=C3CCNC4=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FP1-24 Related Classifications
HY-181585 Related Classifications
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