Fermt3 - fermitin family member 3 Gene

Also Known as Kindlin3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 108101

Summary

Enables Integrin binding activity. Involved in several processes, including Integrin activation; platelet aggregation; and regulation of cell-cell adhesion mediated by Integrin. Located in podosome. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; liver; and lung. Used to study leukocyte adhesion deficiency 3. Human ortholog(s) of this gene implicated in leukocyte adhesion deficiency 1 and leukocyte adhesion deficiency 3. Orthologous to human FERMT3 (FERM domain containing kindlin 3). [provided by Alliance of Genome Resources, Apr 2022]

Fermt3 Products (2)

mRNA Protein Name
NM_001362399.1 NP_001349328.1 fermitin family homolog 3
NM_153795.2 NP_722490.1 fermitin family homolog 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables integrin binding IDA
IDA: Inferred from direct assay
18278053 MGI
enables integrin binding IPI
IPI: Inferred from physical interaction
19234461 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18278053 MGI
Biological Process GO Annotation Evidence Références Source
involved in integrin activation IMP
IMP: Inferred from mutant phenotype
18278053 MGI
involved in leukocyte cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
19234461 MGI
involved in platelet aggregation IMP
IMP: Inferred from mutant phenotype
18278053 MGI
involved in regulation of cell-cell adhesion mediated by integrin IMP
IMP: Inferred from mutant phenotype
19234461 MGI
Cellular Component GO Annotation Evidence Références Source
located in podosome IDA
IDA: Inferred from direct assay
16876785 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fermitin family homolog 3

  • unc-112-related protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS04866 FERMT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21130 Fermt3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27648 Fermt3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fermt3 NCBI NCBI:83706