Ghrh - growth hormone releasing hormone Gene

Also Known as GRF; Ghrf

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14601

Summary

This gene encodes a hormone that has stimulatory effects on pituitary growth hormone synthesis and release, and somatotrope expansion. The encoded preproprotein undergoes proteolytic processing to generate the mature peptide that is secreted by hypothalamus. Mice lacking the encoded protein are deficient in the growth hormone, live longer and exhibit growth retardation, enhanced Insulin sensitivity and increased xenobiotic metabolism. [provided by RefSeq, Jul 2016]

Ghrh Products (2)

mRNA	Protein	Name
NM_001329683.1	NP_001316612.1	somatoliberin preproprotein
NM_010285.3	NP_034415.1	somatoliberin preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables growth hormone-releasing hormone receptor binding	IPI IPI: Inferred from physical interaction	11773624	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10537133	MGI

Biological Process GO Annotation	Evidence	Références	Source
acts upstream of or within adenohypophysis development	IMP IMP: Inferred from mutant phenotype	15985453	MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	10537133	MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI IGI: Inferred from genetic interaction	1334535	MGI
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11773624	MGI
acts upstream of or within growth hormone secretion	IDA IDA: Inferred from direct assay	15070777	MGI
acts upstream of or within growth hormone secretion	IMP IMP: Inferred from mutant phenotype	9348175	MGI
acts upstream of hormone secretion	IMP IMP: Inferred from mutant phenotype	15985453	MGI
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	11773624	MGI
acts upstream of or within positive regulation of hormone secretion	IMP IMP: Inferred from mutant phenotype	9348175	MGI
acts upstream of or within positive regulation of multicellular organism growth	IGI IGI: Inferred from genetic interaction	16246898	MGI
acts upstream of or within positive regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	15985453	MGI
acts upstream of or within response to food	IDA IDA: Inferred from direct assay	16513828	MGI

Cellular Component GO Annotation	Evidence	Références	Source
located in extracellular space	IDA IDA: Inferred from direct assay	7867561	MGI
located in terminal bouton	IDA IDA: Inferred from direct assay	7694848	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
somatoliberin	growth hormone-releasing factor

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P0089A	Human growth hormone-releasing factor TFA	Activator	99.49%	Unkown
HY-P3304	MR 409	Agonist	99.98%	Unkown
HY-P3397A	JV-1-36 acetate	Antagonist	99.93%	Unkown
HY-P0089	Human growth hormone-releasing factor	Activator	98.63%	Unkown
HY-P3397	JV-1-36	Antagonist	/	Unkown
HY-P3594	[His1,Nle27] GHRF (1-32), amide, human	Activator	/	Unkown
HY-P3595	GHRF, porcine	Activator	/	Unkown
HY-RS05413	GHRH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16752	Ghrh Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23191	Ghrh Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ghrh	NCBI	NCBI:2691