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Notch2 - notch 2 Gene

Also Known as N2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18129

Summary

Enables NF-kappaB binding activity and enzyme binding activity. Involved in several processes, including heart looping; left/right axis specification; and marginal zone B cell differentiation. Acts upstream of or within several processes, including animal organ development; cholangiocyte proliferation; and positive regulation of BMP signaling pathway. Located in cilium and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study Hajdu-Cheney syndrome and pre-eclampsia. Human ortholog(s) of this gene implicated in Alagille syndrome and Hajdu-Cheney syndrome. Orthologous to human NOTCH2 (Notch receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Notch2 Products (1)

mRNA	Protein	Name
NM_010928.2	NP_035058.2	neurogenic locus notch homolog protein 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables NF-kappaB binding	IPI IPI: Inferred from physical interaction	18710934	MGI
enables enzyme binding	IPI IPI: Inferred from physical interaction	17573339	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9111338	MGI

Biological Process GO Annotation	Evidence	Références	Source
acts upstream of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	23676271	MGI
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	34635817	MGI
acts upstream of or within activation of protein kinase B activity	IDA IDA: Inferred from direct assay	34635817	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	23676271	MGI
acts upstream of or within cholangiocyte proliferation	IMP IMP: Inferred from mutant phenotype	25446530	MGI
acts upstream of or within ciliary body morphogenesis	IMP IMP: Inferred from mutant phenotype	23676271	MGI
acts upstream of or within defense response to bacterium	IMP IMP: Inferred from mutant phenotype	23913046	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	12730124	MGI
acts upstream of or within embryonic limb morphogenesis	IGI IGI: Inferred from genetic interaction	16169548	MGI
involved in glomerular capillary formation	IEP IEP: Inferred from expression pattern	15821257	MGI
involved in heart looping	IGI IGI: Inferred from genetic interaction	12730124	MGI
acts upstream of or within hepatocyte proliferation	IMP IMP: Inferred from mutant phenotype	25446530	MGI
acts upstream of or within humoral immune response	IGI IGI: Inferred from genetic interaction	17658279	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	17359302	MGI
acts upstream of or within inflammatory response to antigenic stimulus	IGI IGI: Inferred from genetic interaction	17658279	MGI
acts upstream of or within interleukin-4 production	IGI IGI: Inferred from genetic interaction	17658279	MGI
acts upstream of or within intrahepatic bile duct development	IMP IMP: Inferred from mutant phenotype	25446530	MGI
involved in left/right axis specification	IGI IGI: Inferred from genetic interaction	12730124	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	25446530	MGI
acts upstream of or within liver morphogenesis	IMP IMP: Inferred from mutant phenotype	25446530	MGI
involved in marginal zone B cell differentiation	IMP IMP: Inferred from mutant phenotype	19217325	MGI
acts upstream of or within morphogenesis of an epithelial sheet	IMP IMP: Inferred from mutant phenotype	11861489	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	25446530	MGI
acts upstream of or within myeloid dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	23913046	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23676271	MGI
acts upstream of or within placenta blood vessel development	IMP IMP: Inferred from mutant phenotype	17359302	MGI
acts upstream of or within placenta development	IMP IMP: Inferred from mutant phenotype	17359302	MGI
involved in podocyte development	IEP IEP: Inferred from expression pattern	15821257	MGI
acts upstream of or within positive regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	23676271	MGI
acts upstream of or within positive regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	16169548	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	23676271	MGI
involved in positive regulation of osteoclast differentiation	IDA IDA: Inferred from direct assay	18710934	MGI
involved in proximal tubule development	IEP IEP: Inferred from expression pattern	15821257	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	25446530	MGI
involved in wound healing	IDA IDA: Inferred from direct assay	12496659	MGI

Cellular Component GO Annotation	Evidence	Références	Source
located in cilium	IDA IDA: Inferred from direct assay	21703454	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12496659	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	34635817	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
neurogenic locus notch homolog protein 2	Motch B Notch gene homolog 2

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-15670	BMS-906024	Inhibitor	99.91%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-P99320	Tarextumab	Inhibitor	99.83%	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-N6727	Gliotoxin		99.51%	Unkown
HY-RS09448	NOTCH2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS09450	NOTCH2NLC Human Pre-designed siRNA Set A		/	Unkown
HY-RS19796	Notch2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09449	NOTCH2NLA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26292	Notch2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P990206	Anti-Mouse Jagged 2 Antibody (HMJ2-1)	Inhibitor	/	Unkown
HY-P992278	Anti-Notch2 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Notch2	NCBI	NCBI:4853