FHIT - fragile histidine triad diadenosine triphosphatase Gene

Also Known as FRA3B; AP3Aase

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2272

About FHIT

Cytogenetic location: 3p14.2 Genomic coordinates (GRCh38): 3:59,747,277-61,251,452 (from NCBI)

This gene has 8 transcripts (splice variants), 126 orthologues, 2 paralogues and is associated with 74 phenotypes. Ubiquitous expression in gall bladder (RPKM 2.2), lymph node (RPKM 1.6) and 25 other tissues.

Summary

The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]

FHIT Products (7)

mRNA Protein Name
NM_001166243.3 NP_001159715.1 bis(5'-adenosyl)-triphosphatase isoform 1
NM_001320899.2 NP_001307828.1 bis(5'-adenosyl)-triphosphatase isoform 1
NM_001320900.2 NP_001307829.1 bis(5'-adenosyl)-triphosphatase isoform 1
NM_001320901.2 NP_001307830.1 bis(5'-adenosyl)-triphosphatase isoform 2
NM_001354589.2 NP_001341518.1 bis(5'-adenosyl)-triphosphatase isoform 3
NM_001354590.2 NP_001341519.1 bis(5'-adenosyl)-triphosphatase isoform 3
NM_002012.4 NP_002003.1 bis(5'-adenosyl)-triphosphatase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables adenosine 5'-monophosphoramidase activity IDA
IDA: Inferred from direct assay
18694747 GOA
enables adenylylsulfatase activity IDA
IDA: Inferred from direct assay
18694747 GOA
enables adenylylsulfate-ammonia adenylyltransferase activity IDA
IDA: Inferred from direct assay
26181368 GOA
enables bis(5'-adenosyl)-triphosphatase activity IDA
IDA: Inferred from direct assay
8794732 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
9261067 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18077326 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
15313915 GOA
Biological Process GO Annotation Evidence Références Source
involved in diadenosine triphosphate catabolic process IDA
IDA: Inferred from direct assay
8794732 GOA
involved in intrinsic apoptotic signaling pathway by p53 class mediator IMP
IMP: Inferred from mutant phenotype
15313915 GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
15313915 GOA
involved in purine nucleotide metabolic process IDA
IDA: Inferred from direct assay
9323207 GOA
Cellular Component GO Annotation Evidence Références Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15007172 GOA
located in cytosol IDA
IDA: Inferred from direct assay
15313915 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FHIT Protein Structure

HIT

HIT: HIT domain (11 - 103)

  • 0
  • 100
  • 147 a.a.
Protein Preferred Names Protein Names

bis(5'-adenosyl)-triphosphatase

  • AP3A hydrolase

FHIT Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
FHIT P49789 CTNNB1 Homo sapiens P35222
Pull Down
18077326
Intra
FHIT P49789 CTNNB1 Homo sapiens P35222
Anti Bait CoIP
18077326
Intra
FHIT P49789 CTNNB1 Homo sapiens P35222
Anti Tag CoIP
18077326
Intra
FHIT P49789 FHIT Homo sapiens P49789
Pull Down
18077326
Intra
FHIT P49789 FHIT Homo sapiens P49789
Validated Y2H
27107012
Intra
FHIT P49789 FHIT Homo sapiens P49789
Y2H Array
31515488
Intra
FHIT P49789 FHIT Homo sapiens P49789
Y2H Array
24722188
Intra
FHIT P49789 FHIT Homo sapiens P49789
BFG-2H
27107012
Intra
FHIT P49789 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
FHIT P49789 FHIT Homo sapiens P49789
Y2H Pooling
16189514
Intra
FHIT P49789 MTMR6 Homo sapiens Q9Y217
Anti Tag CoIP
33961781
Intra
FHIT P49789 RAB40B Homo sapiens Q12829
Y2H Array
21988832
Intra
FHIT P49789 MTMR6 Homo sapiens Q9Y217-2
Anti Tag CoIP
28514442
Intra
FHIT P49789 FHIT Homo sapiens P49789
Validated Y2H
32296183
Intra
FHIT P49789 FHIT Homo sapiens P49789
Y2H Array
25416956
Intra
FHIT P49789 FHIT Homo sapiens P49789
X-Ray Diffraction
9576908
Intra
FHIT P49789 FHIT Homo sapiens P49789
X-Ray Diffraction
9261067
Intra
FHIT P49789 FHIT Homo sapiens P49789
Y2H Array
32296183
Intra
FHIT P49789 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra
FHIT P49789 FHIT Homo sapiens P49789
Y2H Prey Pooling
32296183
Intra
FHIT P49789 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FHIT Proteins

Cat. No. Nom du produit Accession Pureté
HY-P75187 FHIT Protein, Human (His) P49789 (M1-Q147) ≥ 95%, as determined by reducing SDS-PAGE.

FHIT Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P810873 FHIT Antibody WB, IHC-P, ICC/IF Human
HY-P811178 Phospho-FHIT (Tyr114) Antibody WB, IHC-P, ICC/IF Human, Mouse
HY-P82932 FHIT Antibody (YA2677) WB Human, Rat

Related Diseases

Diseases Alias
Renal Cell Carcinoma, Nonpapillary

  • Renal Cell Carcinoma

  • RCC

  • Nonpapillary Renal Cell Carcinoma

  • Clear Cell Renal Cell Carcinoma

  • Hypernephroma

  • Adenocarcinoma Of Kidney

  • Renal Carcinoma, Chromophobe, Somatic

  • Clear Cell Carcinoma Of Kidney

  • Clear-Cell Metastatic Renal Cell Carcinoma

  • Clear Cell Renal Carcinoma

  • Renal Cell Carcinoma, Somatic

  • Conventional Renal Cell Carcinoma

  • Conventional Renal Cell Carcinoma

  • Renal Clear Cell Carcinoma

  • Ccrcc

  • Hereditary Clear Cell Renal Cell Carcinoma

  • Carcinoma, Renal Cell

  • Renal Cell Carcinoma, Clear Cell, Somatic

  • Renal Cell Carcinoma, Clear Cell

  • Clear Cell Kidney Carcinoma

  • Clear Cell Rcc

  • Cystic-Multilocular Variant

  • Clear Cell Renal Cell Adenocarcinoma

  • Hereditary Clear Cell Renal Cell Adenocarcinoma

  • Common Renal Cell Carcinoma

  • Crcc

  • Renal Cell Carcinoma Non-Papillary

  • Carcinoma Renal Cell

  • Renal Cell Cancer

  • Carcinoma, Renal Cell, Nonpapillary
Sporadic Breast Cancer

  • Sporadic Breast Carcinoma
Megacolon

  • Dilatation Of Colon
Cervical Intraepithelial Neoplasia

  • CIN
Bilateral Breast Cancer

  • Bilateral Breast Carcinoma
Muir-Torre Syndrome

  • MRTES

  • Keratoacanthoma

  • Muir-Torré Syndrome

  • Cutaneous Sebaceous Neoplasms And Keratoacanthomas, Multiple, With Gastrointestinal And Other Carcinomas

  • Cutaneous Sebaceous Neoplasms And Keratoacanthomas Multiple With Gastrointestinal And Other Carcinomas

  • Multiple Keratoacanthoma, Muir-Torre Type

  • Mts

  • Torre-Muir Syndrome
Hereditary Conventional Renal Cell Carcinoma
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Suppressor Of Tumorigenicity 3

  • Cervical Carcinoma

  • ST3

  • Tumor-Suppressor Gene, Hela Cell Type

  • Tshl

  • Cervical Carcinoma, Tumor-Suppressor Gene Involved In

  • Ccts

  • Cervix Carcinoma
Human Papillomavirus Infectious Disease

  • Hpv

  • Papillomavirus Infections

  • Human Papilloma Virus Infection
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Lung Benign Neoplasm

  • Lung Neoplasms

  • Tumor Of The Lung

  • Lung Tumor
Laryngeal Squamous Cell Carcinoma

  • Epidermoid Carcinoma Of The Larynx

  • Squamous Cell Carcinoma Of Larynx

  • Squamous Cell Carcinoma Of The Larynx

  • Squamous Cell Carcinoma Of Head And Neck
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Bronchiolo-Alveolar Adenocarcinoma

  • Bronchioloalveolar Carcinoma

  • Bronchioalveolar Lung Carcinoma

  • Minimally Invasive Lung Adenocarcinoma

  • Carcinoma Bronchioloalveolar

  • Adenocarcinoma, Bronchiolo-Alveolar

  • Bronchioloalveolar Adenocarcinoma
Kidney Cancer

  • Renal Cancer

  • Renal Carcinoma

  • Kidney Neoplasm

  • Malignant Neoplasm Of Kidney Except Pelvis

  • Malignant Tumour Of Kidney

  • Kidney Neoplasms

  • Cancer, Kidney

  • Cancer, Renal

  • Malignant Neoplasm Of Kidney

  • Renal Cell Carcinoma
Transitional Cell Carcinoma

  • Transitional Cell Neoplasm

  • Carcinoma, Transitional Cell

  • Transitional Carcinoma

  • Transitional Cell Tumor

  • Urothelial Cell Carcinoma

  • Carcinoma Transitional Cell

  • Transitional Cell Carcinoma Of Bladder
Cervical Cancer

  • Cervical Cancer, Somatic

  • Neoplasm Of Uterine Cervix

  • Cervix Cancer

  • Uterine Cervical Neoplasm

  • Cervical Neoplasm

  • Cervix Uteri Cancer

  • Tumor Of The Cervix Uteri

  • CERCA

  • Uterine Cervical Cancer

  • Neoplasms Cervical

  • Uterine Cervical Neoplasms

  • Cervical Cancers

  • Cancer, Cervical, Somatic

  • Malignant Tumor Of Cervix

  • Cervix Carcinoma
Hereditary Renal Cell Carcinoma
Bronchus Cancer

  • Malignant Neoplasm Of Bronchus And Lung

  • Bronchus Carcinoma

  • Bronchogenic Carcinoma

  • Malignant Neoplasm Of Bronchus Or Lung

  • Bc - Bronchogenic Carcinoma

  • Carcinoma, Bronchogenic

  • Bronchial Neoplasms
Pleomorphic Adenoma

  • Mixed Tumor Of The Salivary Gland

  • Adenoma Pleomorphic

  • Adenoma, Pleomorphic

  • Mixed Salivary Gland Tumor

  • Mixed Tumor, Not Otherwise Specified
Gastric Adenocarcinoma

  • Adenocarcinoma Of Stomach

  • Stomach Adenocarcinoma

  • Adenocarcinoma Gastric

  • Intestinal Type Adenocarcinoma Of Unspecified Site

  • Diffuse Type Adenocarcinoma Of Unspecified Site
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Endometrial Cancer

  • Endometrial Carcinoma

  • Endometrial Neoplasm

  • Malignant Neoplasm Of Endometrium

  • Endometrioid Carcinoma

  • Endometrial Neoplasms

  • Carcinoma, Endometrioid

  • Endometrial Cancer, Familial

  • Endometrial Carcinoma, Somatic

  • Endometrial Cancer, Susceptibility To

  • Endometrial Ca

  • Malignant Endometrial Neoplasm

  • Neoplasm Of Endometrium

  • Primary Malignant Neoplasm Of Endometrium

  • Tumor Of Endometrium

  • Carcinoma Of The Endometrium

  • Endometrioid Carcinoma Of Female Reproductive System

  • ENDMC

  • Carcinoma Endometrioid

  • Endometrial Cancers

  • Cancer, Endometrial

  • Uterine Corpus Cancer
Squamous Cell Carcinoma

  • Epidermoid Carcinoma

  • Squamous Cell Cancer

  • Carcinoma, Squamous Cell

  • Squamous Cell Skin Cancer

  • Malignant Squamous Cell Tumor

  • Squamous Carcinoma

  • Squamous Cell Epithelioma

  • Carcinoma Squamous Cell

  • Neoplasms, Squamous Cell

  • Squamous Cell Carcinoma - Category

  • Malignant Squamous Cell Neoplasm

  • Squamous Cell Carcinoma Of Skin
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Gallbladder Cancer

  • Gallbladder Carcinoma

  • Gallbladder Neoplasm

  • Malignant Neoplasm Of Gallbladder

  • Malignant Tumour Of Gallbladder

  • Gallbladder Ca

  • Localized Malignant Gallbladder Neoplasm

  • Malignant Tumor Of The Gallbladder

  • Tumor Of The Gallbladder

  • Cancer Of The Gallbladder

  • Carcinoma Gallbladder

  • Carcinoma Of Gallbladder

  • Gallbladder Neoplasms

  • Malignant Neoplasm Of Gallbladder Localized

  • Cancer Of Gallbladder

  • Primary Malignant Neoplasm Of Gallbladder
Esophageal Cancer

  • Esophageal Carcinoma

  • Carcinoma Of Esophagus

  • Esophageal Squamous Cell Carcinoma, Somatic

  • Esophageal Carcinoma, Somatic

  • Esophagus Cancer

  • Gastric Cardia Adenocarcinoma

  • Esophageal Neoplasms

  • Esophageal Cancer, Somatic

  • Cancer Of Esophagus

  • Cancer Of Oesophagus

  • Carcinoma Of Oesophagus

  • Ca Lower Third Oesophagus

  • Ca Middle Third Oesophagus

  • Malignant Neoplasm Of Distal Third Of Esophagus

  • Malignant Neoplasm Of Lower Third Of Oesophagus

  • Malignant Neoplasm Of Middle Third Of Oesophagus

  • Malignant Neoplasm Of Proximal Third Of Esophagus

  • Malignant Neoplasm Of Upper Third Esophagus

  • Malignant Tumor Of Abdominal Esophagus

  • Malignant Tumor Of Distal Third Of Esophagus

  • Malignant Tumor Of Proximal Third Of Esophagus

  • Malignant Tumor Of The Middle Third Of The Esophagus

  • ESCR

  • Aerodigestive Tract Cancer

  • Escc

  • Esophageal Squamous Cell Carcinoma

  • Cancer, Esophageal

  • Malignant Neoplasm Of Esophagus

  • Squamous Cell Carcinoma Of Esophagus

  • Malignant Neoplasm Of Middle Third Of Esophagus
Adenosquamous Carcinoma

  • Adenosquamous Cell Carcinoma

  • Mixed Adenocarcinoma And Squamous Carcinoma

  • Carcinoma Adenosquamous

  • Carcinoma, Adenosquamous
Vallecula Cancer

  • Malignant Tumor Of Vallecula
Myelodysplastic Syndrome

  • Myelodysplastic Syndromes

  • Myelodysplasia

  • MDS

  • Myelodysplastic Syndrome Included

  • Myelodysplastic Syndrome, Susceptibility To, Included

  • Myelodysplastic Syndrome, Somatic

  • Myelodysplastic Syndrome, Susceptibility To
Uterus Carcinoma In Situ
Merkel Cell Carcinoma

  • Trabecular Adenocarcinoma

  • Cutaneous Neuroendocrine Carcinoma

  • Trabecular Carcinoma

  • Carcinoma, Merkel Cell

  • Merkel Cell Cancer

  • Merkle Tumors

  • Mcc

  • Carcinoma Merkel Cell
Cervix Uteri Carcinoma In Situ

  • Carcinoma In Situ Of Cervix

  • Carcinoma In Situ Of Uterine Cervix

  • Cervical Intraepithelial Neoplasia

  • Carcinoma Of Cervix Stage 0

  • Cervical Intraepithelial Neoplasia Grade Iii With Severe Dysplasia

  • Cervix Ca In Situ

  • Cin Iii

  • Cin Iii - Carcinoma In Situ Of Cervix

  • Cin Iii - Severe Dyskaryosis

  • Severe Dysplasia Of Cervix

  • Severe Dysplasia Of The Cervix Uteri

  • Squamous Intraepithelial Neoplasia, Grade Iii

  • Cervix Intraepithelial Neoplasia Grade 3 Ajcc V7
Bladder Cancer

  • Urinary Bladder Cancer

  • Bladder Carcinoma

  • Urinary Bladder Carcinoma

  • Bladder Neoplasm

  • Bladder Tumor

  • Cancer, Bladder

  • Malignant Neoplasm Of Urinary Bladder

  • Carcinoma Of Bladder

  • Bladder Cancer, Somatic

  • Tumor Of The Bladder

  • Carcinoma Of Urinary Bladder

  • Bladder Carcinoma Urinary

  • Cancer Of The Urinary Bladder

  • Cancer, Urinary Bladder

  • Malignant Bladder Neoplasm

  • Malignant Bladder Tumor

  • Neoplasm Of The Bladder

  • Neoplasm Of The Urinary Bladder

  • Tumor Of The Urinary Bladder

  • Urinary Bladder Neoplasm

  • BLC

  • Urothelial Carcinoma Of The Bladder

  • Bladder Tumors

  • Urinary Bladder Neoplasms

  • Bladder Cancer Nos

  • Vesical Cancer Nos

  • Malignant Neoplasm Of Bladder, Part Unspecified

  • Malignant Tumour Of Urinary Bladder

  • Primary Malignant Neoplasm Of Bladder
Megaesophagus

  • Esophageal Achalasia
Ocular Cancer

  • Eye Neoplasm

  • Eye Carcinoma

  • Eye Cancer

  • Eye Neoplasms

  • Malignant Eye Neoplasm

  • Neoplasm Of Eye

  • Neoplasm Of Eye Proper

  • Ocular Tumor

  • Carcinoma Of Eye

  • Ocular Carcinoma

  • Malignant Tumor Of Eye
Barrett Esophagus

  • Barrett'S Esophagus

  • Barrett Esophagus/Esophageal Adenocarcinoma

  • Barrett Metaplasia

  • Barrett'S Ulcer Of Esophagus

  • Ulcerative Esophagitis

  • Barrett'S Esophagus With Esophagitis

  • Barrett'S Oesophagus

  • Barretts Syndrome

  • Barrett Syndrome

  • BE

  • Peptic Ulcer Of Esophagus

  • Adenocarcinoma Of Esophagus
Squamous Cell Carcinoma, Head And Neck

  • Squamous Cell Carcinoma Of The Head And Neck

  • HNSCC

  • Head And Neck Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Lip

  • Squamous Cell Carcinoma, Head And Neck, Somatic

  • Carcinoma Of The Head And Neck

  • Squamous Cell Carcinomas Of Head And Neck

  • Scchn

  • Squamous Cell Carcinoma Of The Hypopharynx

  • Squamous Cell Carcinoma Of The Oropharynx

  • Squamous Cell Carcinoma Of Salivary Glands

  • Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses

  • Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses

  • Squamous Cell Carcinoma Of The Oral Cavity

  • Squamous Cell Carcinoma Of The Lip

  • Carcinoma, Squamous Cell Of Head And Neck

  • Lip Squamous Cell Carcinoma

  • Carcinoma, Squamous Cell, Head And Neck

  • Salivary Gland Squamous Cell Carcinoma

  • Cancer Of Head And Neck

  • Squamous Cell Carcinoma Of Oropharynx Nos
Cholangiocarcinoma

  • Cholangiocarcinoma, Susceptibility To

  • Extrahepatic Cholangiocarcinoma

  • Intrahepatic Cholangiocarcinoma

  • Chlc

  • Chlc, Susceptibility To

  • Cc

  • Cholangiocarcinoma Of Biliary Tract

  • Cholangiocellular Carcinoma

  • Distal Cholangiocarcinoma

  • Perihilar Cholangiocarcinoma

  • Bile Duct Cancer

  • Cca

  • Adult Primary Cholangiocellular Carcinoma

  • Bile Duct Carcinoma
Cervical Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of The Cervix Uteri

  • Squamous Cell Carcinoma Of Cervix
Chronic Fatigue Syndrome

  • Myalgic Encephalomyelitis

  • Postviral Fatigue Syndrome

  • Cfs

  • Myalgic Encephalitis

  • Encephalomyelitis, Myalgic

  • Chronic Fatigue

  • Fatigue Syndrome, Chronic

  • Benign Myalgic Encephalomyelitis

  • Akureyri

  • Akureyri Disease

  • Cfs - [Chronic Fatigue Syndrome]

  • Epidemic Neuromyasthenia

  • Myalgic Encephalomyelitis Syndrome

  • Me - [Myalgic Encephalomyelitis]

  • Pvfs - [Postviral Fatigue Syndrome]

  • Neuromyasthenia

  • Iceland Disease

  • Icelandic Disease
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Breast Disease

  • Breast Diseases
Hypermethioninemia Due To Adenosine Kinase Deficiency

  • Adk Hypermethioninemia

  • Hypermethioninemia Encephalopathy Due To Adenosine Kinase Deficiency

  • Hypermethioninemia Encephalopathy Due To Adk Deficiency

  • Mrt8

  • Mental Retardation, Autosomal Recessive 8, Formerly

  • Mrt8, Formerly

  • HMAKD

  • Mental Retardation, Autosomal Recessive 8
Small Intestine Leiomyosarcoma

  • Leiomyosarcoma Of The Small Bowel

  • Smooth Muscle Connective Tissue Tumor

  • Leiomyosarcoma Of Small Intestine
Interstitial Lung Disease 2

  • Idiopathic Pulmonary Fibrosis

  • Ipf

  • Fibrocystic Pulmonary Dysplasia

  • Pulmonary Fibrosis, Idiopathic

  • Pulmonary Fibrosis, Idiopathic, Susceptibility To

  • Cryptogenic Fibrosing Alveolitis

  • ILD2

  • Idiopathic Pulmonary Fibrosis, Familial

  • Fibrosing Alveolitis, Cryptogenic

  • Uip

  • Fibrosing Alveolitis

  • Interstitial Pneumonitis, Usual

  • Familial Idiopathic Pulmonary Fibrosis

  • Idiopathic Fibrosing Alveolitis, Chronic Form

  • Usual Interstitial Pneumonia

  • Fibrosing Alveolitis Cryptogenic

  • Hamman-Rich Disease

  • Idiopathic Pulmonary Fibrosis Familial

  • Interstitial Pneumonitis Usual

  • Fibrosis Idiopathic Pulmonary

  • Fibrosis, Pulmonary, Idiopathic

  • Hamman-Rich Syndrome

  • Chronic Idiopathic Pulmonary Fibrosis

  • Acute Interstitial Pneumonia

  • Interstitial Pulmonary Fibrosis

  • Ipf - [Idiopathic Pulmonary Fibrosis]

  • Idiopathic Lung Fibrosis

  • Fibrosing Lung Disease

  • Pulmonary Fibrosis Nos

  • Fibrosing Pneumonitis
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Lung Cancer Susceptibility 3

  • Lung Adenocarcinoma

  • Adenocarcinoma Of Lung

  • LNCR3

  • Adenocarcinoma Of Lung, Susceptibility To

  • Bronchogenic Lung Adenocarcinoma

  • Nonsmall Cell Adenocarcinoma

  • Adenocarcinoma Lung

  • Lung Adenocarcinomas

  • Non-Small Cell Adenocarcinoma
Leukemia, Acute Lymphoblastic

  • Acute Lymphoblastic Leukemia

  • ALL

  • Acute Lymphocytic Leukemia

  • Leukemia, Acute Lymphocytic, Susceptibility To, 1

  • Acute Lymphoblastic Leukaemia

  • Precursor Lymphoblastic Lymphoma/Leukemia

  • Precursor Lymphoid Neoplasm

  • Leukemia, Acute Lymphoblastic, Susceptibility To

  • B-Cell Acute Lymphoblastic Leukemia

  • Leukemia, Acute Lymphocytic 1

  • Acute Lymphocytic Leukaemia

  • Acute Lymphoblastic Leukemia/Lymphoma

  • All1

  • Childhood Acute Lymphoblastic Leukemia

  • Leukemia Acute Lymphoblastic 1

  • Leukemia Acute Lymphoblastic B-Hyperdiploid

  • Leukemia Acute Lymphocytic

  • Leukemia Acute Lymphocytic 1

  • Leukemia B-Cell Acute Lymphoblastic

  • Leukemia T-Cell Acute Lymphoblastic

  • Leukemia, Acute Lymphoblastic, 3

  • ALL3

  • Lymphoblastic Leukemia Acute

  • Leukemia, Acute, Lymphoblastic

  • Precursor Cell Lymphoblastic Leukemia Lymphoma

  • Leukemia, Lymphocytic, Acute, L1

  • Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS04933 FHIT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-158845 8Br-HA Inducer / Unkown
HY-RS19329 Fhit Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25820 Fhit Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus FHIT VGNC VGNC:80046
Canis familiaris FHIT VGNC VGNC:40870
Rattus norvegicus FHIT RGD RGD:620448
Macaca mulatta FHIT VGNC VGNC:84181
Mus musculus FHIT MGD MGI:1277947
Bos taurus FHIT VGNC VGNC:28998
Others FHIT NCBI