SNX33 - sorting nexin 33 Gene

Also Known as SNX30; SH3PX3; SH3PXD3C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 257364

About SNX33

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:75,647,912-75,662,301 (from NCBI)

This gene has 2 transcripts (splice variants), 204 orthologues and 15 paralogues. Ubiquitous expression in esophagus (RPKM 14.6), ovary (RPKM 14.1) and 24 other tissues.

Summary

The protein encoded by this gene is involved in cytoskeletal reorganization, vesicle trafficking, endocytosis, and Mitosis. The encoded protein is essential for the creation of the cleavage furrow during Mitosis and for completion of Mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

SNX33 Products (2)

mRNA	Protein	Name
NM_001318146.1	NP_001305075.1	sorting nexin-33 isoform 2
NM_153271.2	NP_695003.1	sorting nexin-33 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	19487689	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16374509	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in cleavage furrow formation	IMP IMP: Inferred from mutant phenotype	22718350	GOA
involved in endocytosis	IMP IMP: Inferred from mutant phenotype	22718350	GOA
involved in endosomal transport	IMP IMP: Inferred from mutant phenotype	22718350	GOA
involved in endosome organization	IMP IMP: Inferred from mutant phenotype	21048941	GOA
involved in macropinocytosis	IMP IMP: Inferred from mutant phenotype	21048941	GOA
involved in mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	22718350	GOA
involved in negative regulation of endocytosis	IDA IDA: Inferred from direct assay	18353773	GOA
involved in negative regulation of protein localization to cell surface	IDA IDA: Inferred from direct assay	18419754	GOA
involved in plasma membrane tubulation	IDA IDA: Inferred from direct assay	20964629	GOA
involved in positive regulation of membrane protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	18353773	GOA
involved in positive regulation of protein localization to cell surface	IDA IDA: Inferred from direct assay	18353773	GOA
involved in protein import	IDA IDA: Inferred from direct assay	18353773	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	22718350	GOA
located in cytosol	IDA IDA: Inferred from direct assay	18353773	GOA
located in membrane	IDA IDA: Inferred from direct assay	18353773	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX33 Protein Structure

SH3_9

PX

BAR_3_WASP_bdg

0
100
200
300
400
500
574 a.a.

Protein Preferred Names	Protein Names
sorting nexin-33	SH3 and PX domain containing 3

SNX33 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	SNX33	Q8WV41	SNX33	Homo sapiens	Q8WV41	Anti Tag CoIP	19487689
Intra	SNX33	Q8WV41	DNM1	Homo sapiens	Q05193	Anti Tag CoIP	33961781
Intra	SNX33	Q8WV41	FASLG	Homo sapiens	P48023	Anti Tag CoIP	19807924
Intra	SNX33	Q8WV41	SNX33	Homo sapiens	Q8WV41	Pull Down	23085988
Intra	SNX33	Q8WV41	DNM1	Homo sapiens	Q05193	Anti Tag CoIP	18353773
Intra	SNX33	Q8WV41	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	33961781
Intra	SNX33	Q8WV41	NAF1	Homo sapiens	Q96HR8	Validated Y2H	32296183
Intra	SNX33	Q8WV41	ADAM15	Homo sapiens	Q13444	Phage Display	16374509
Intra	SNX33	Q8WV41	FASLG	Homo sapiens	P48023	Phage Display	19807924
Intra	SNX33	Q8WV41	WAS	Homo sapiens	P42768	Anti Tag CoIP	19487689
Intra	SNX33	Q8WV41	DNM2	Homo sapiens	P50570	Anti Tag CoIP	33961781
Intra	SNX33	Q8WV41	SNX9	Homo sapiens	Q9Y5X1	Anti Tag CoIP	19487689
Intra	SNX33	Q8WV41	SNX9	Homo sapiens	Q9Y5X1	Pull Down	23085988

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS13542	SNX33 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SNX33	RGD	RGD:1307898
Bos taurus	SNX33	VGNC	VGNC:35110
Canis familiaris	SNX33	VGNC	VGNC:46640
Macaca mulatta	SNX33	VGNC	VGNC:77784
Mus musculus	SNX33	MGD	MGI:2443239
Felis catus	SNX33	VGNC	VGNC:65556
Others	SNX33	NCBI