RAP2C - RAP2C, member of RAS oncogene family Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57826

About RAP2C

Cytogenetic location: Xq26.2 Genomic coordinates (GRCh38): X:132,203,025-132,219,447 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues and 35 paralogues. Ubiquitous expression in endometrium (RPKM 31.6), bone marrow (RPKM 18.9) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the Ras-related protein subfamily of the Ras GTPase superfamily. Members of this family are small GTPases that act as molecular switches to regulate cellular proliferation, differentiation, and Apoptosis. This protein has been reported to activate in vitro transcriptional activity of the serum response element. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

RAP2C Products (3)

mRNA Protein Name
NM_001271186.2 NP_001258115.1 ras-related protein Rap-2c isoform 1 precursor
NM_001271187.2 NP_001258116.1 ras-related protein Rap-2c isoform 2
NM_021183.5 NP_067006.3 ras-related protein Rap-2c isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables GDP binding IDA
IDA: Inferred from direct assay
16213650 GOA
enables GTP binding IDA
IDA: Inferred from direct assay
16213650 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23885123 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
17447155 GOA
Biological Process GO Annotation Evidence Références Source
involved in establishment of endothelial intestinal barrier IGI
IGI: Inferred from genetic interaction
23885123 GOA
involved in establishment of endothelial intestinal barrier IMP
IMP: Inferred from mutant phenotype
23885123 GOA
NOT involved in microvillus assembly IMP
IMP: Inferred from mutant phenotype
22797597 GOA
Cellular Component GO Annotation Evidence Références Source
located in bicellular tight junction IDA
IDA: Inferred from direct assay
23885123 GOA
located in cell-cell contact zone IDA
IDA: Inferred from direct assay
23885123 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17447155 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
16213650 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAP2C Protein Structure

Ras

Ras: Ras family (5 - 164)

  • 0
  • 100
  • 183 a.a.
Protein Preferred Names Protein Names

ras-related protein Rap-2c

  • small GTPase RAP2C

RAP2C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
RAP2C Q9Y3L5 RAP1GDS1 Homo sapiens P52306-5
Y2H Array
32296183
Intra
RAP2C Q9Y3L5 RAP1GDS1 Homo sapiens P52306-5
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS11659 RAP2C Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RAP2C MGD MGI:1919315
Rattus norvegicus RAP2C RGD RGD:1588562
Canis familiaris RAP2C VGNC VGNC:45345
Felis catus RAP2C VGNC VGNC:64491
Bos taurus RAP2C VGNC VGNC:33721
Others RAP2C NCBI