RPS14 - ribosomal protein S14 Gene

Also Known as S14; EMTB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6208

About RPS14

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:150,442,635-150,449,739 (from NCBI)

This gene has 8 transcripts (splice variants), 272 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 306.3), bone marrow (RPKM 258.9) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S11P family of ribosomal proteins. It is located in the cytoplasm. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. In Chinese hamster ovary cells, mutations in this gene can lead to resistance to emetine, a protein synthesis inhibitor. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

RPS14 Products (3)

mRNA	Protein	Name
NM_001025070.2	NP_001020241.1	40S ribosomal protein S14
NM_001025071.2	NP_001020242.1	40S ribosomal protein S14
NM_005617.4	NP_005608.1	40S ribosomal protein S14

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables mRNA 5'-UTR binding	IDA IDA: Inferred from direct assay	7867928	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
enables translation regulator activity	IMP IMP: Inferred from mutant phenotype	3683397	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in cytoplasmic translation	IMP IMP: Inferred from mutant phenotype	9152021	GOA
involved in erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	18202658	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7867928	GOA
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA
involved in translation	IMP IMP: Inferred from mutant phenotype	3683397	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
part of cytosolic small ribosomal subunit	IDA IDA: Inferred from direct assay	8706699	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	9152021	GOA
is active in postsynaptic density	EXP EXP: Inferred from Experiment	21170055	GOA
is active in postsynaptic density	IDA IDA: Inferred from direct assay	21170055	GOA
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS14 Protein Structure

Ribosomal_S11

0
100
151 a.a.

Protein Preferred Names	Protein Names
40S ribosomal protein S14	emetine resistance

RPS14 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	RPS14	P62263	AK6	Homo sapiens	Q9Y3D8	Validated Y2H	25416956
Intra	RPS14	P62263	AK6	Homo sapiens	Q9Y3D8	Anti Tag CoIP	28514442
Intra	RPS14	P62263	RPS3A	Homo sapiens	P61247	Anti Tag CoIP	33961781
Intra	RPS14	P62263	RPS3A	Homo sapiens	P61247	Anti Tag CoIP	28514442
Intra	RPS14	P62263	TAF9	Homo sapiens	Q16594	Y2H Array	16713569
Intra	RPS14	P62263	TAF9	Homo sapiens	Q16594	Anti Tag CoIP	33961781
Intra	RPS14	P62263	TAF9	Homo sapiens	Q16594	Y2H Pooling	16189514
Intra	RPS14	P62263	KRR1	Homo sapiens	Q13601	Validated Y2H	32296183
Intra	RPS14	P62263	KRR1	Homo sapiens	Q13601	Anti Tag CoIP	33961781
Intra	RPS14	P62263	KRR1	Homo sapiens	Q13601	Y2H Array	32296183
Intra	RPS14	P62263	KRR1	Homo sapiens	Q13601	Anti Tag CoIP	28514442
Intra	RPS14	P62263	KRR1	Homo sapiens	Q13601	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Chromosome 5q Deletion Syndrome	5q- Syndrome Mar Myelodysplastic Syndrome Associated With Isolated Del Chromosome Abnormality Macrocytic Anemia, Refractory, Due To 5q Deletion, Somatic 5q Deletion Syndrome 5q Minus Syndrome Refractory Macrocytic Anemia Due To 5q Deletion Myelodysplastic Syndrome With Isolated Del Macrocytic Anemia, Refractory, Due To 5q Deletion 5q- Syndrome, Refractory Macrocytic Anemia Due To 5q Deletion 5q Syndrome Chromosome 5q Deletion Myelodysplastic Syndrome With 5q Deletion Myelodysplastic Syndrome With 5q Deletion Syndrome Anemia, Macrocytic, Refractory, Due To 5q Deletion, Somatic 5q-Syndrome Chromosome 5, Trisomy 5q Loss Of Chromosome 5q 5 Q- Syndrome
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome
Shwachman-Diamond Syndrome 1	Shwachman-Diamond Syndrome Shwachman Syndrome Shwachman-Bodian-Diamond Syndrome Sds Pancreatic Insufficiency And Bone Marrow Dysfunction Shwachman-Bodian Syndrome SDS1 Lipomatosis Of Pancreas, Congenital Congenital Lipomatosis Of Pancreas Shwachman-Diamond Type Metaphyseal Dysplasia Metaphyseal Chondrodysplasia, Shwachman Type Shwachman-Diamond-Oski Syndrome
Dyskeratosis Congenita, X-Linked	DKCX X-Linked Dyskeratosis Congenita Zinsser-Cole-Engman Syndrome Hoyeraal-Hreidarsson Syndrome Dyskeratosis Congenita X-Linked HHS Cerebellar Hypoplasia With Pancytopenia Prenatal Growth Retardation With Progressive Pancytopenia And Cerebellar Hypoplasia Dyskeratosis Congenita
Retinitis Pigmentosa 14	RP14 Retinitis Pigmentosa Juvenile Tulp1-Related Retinitis Pigmentosa-14 Retinitis Pigmentosa, Type 14
Cartilage-Hair Hypoplasia	Metaphyseal Chondrodysplasia, Mckusick Type CHH Mckusick Type Metaphyseal Chondrodysplasia Metaphyseal Dysplasia Without Hypotrichosis Cartilage Hair Hypoplasia Like Syndrome Metaphyseal Chondrodysplasia Mckusick Type Chhv Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency Cartilage-Hair Syndrome Mckusick'S Metaphyseal Chondrodysplasia Syndrome Metaphyseal Chondrodysplasia, Recessive Type Autosomal Recessive Metaphyseal Chondrodysplasia
Macrocytic Anemia	Anemia Macrocytic Anemia, Macrocytic Macrocytic Anaemia
Bowen-Conradi Syndrome	BWCNS Bowen Hutterite Syndrome Bowen-Conradi Hutterite Syndrome Bowen Syndrome, Hutterite Type Bowen Hutterite Syndrome, Formerly Hutterite Syndrome Bowen Syndrome Hutterite Type Fetal Growth Retardation
Treacher Collins Syndrome 1	Treacher Collins Syndrome Mandibulofacial Dysostosis Treacher Collins-Franceschetti Syndrome Tcof Tcs Mfd1 Franceschetti-Klein Syndrome TCS1 Franceschetti Syndrome Franceschetti-Zwahlen-Klein Syndrome Zygoauromandibular Dysplasia Treacher-Collins Syndrome Mandibulofacial Dysostosis Without Limb Anomalies Bilateral And Symmetric Oto-Mandibular Dysplasia
Anauxetic Dysplasia 1	Anauxetic Dysplasia Spondylometaepiphyseal Dysplasia, Menger Type Spondylometaepiphyseal Dysplasia, Anauxetic Type Spondyloepimetaphyseal Dysplasia, Anauxetic Type ANXD1 Anxd Spondylometaepiphyseal Dysplasia Anauxetic Type Spondylometaepiphyseal Dysplasia Menger Type Ad Spondyloepimetaphyseal Dysplasia, Menger Type Dysplasia, Anauxetic, Type 1
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS12224	RPS14 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21742	Rps14 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28259	Rps14 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RPS14	VGNC	VGNC:64751
Rattus norvegicus	RPS14	RGD	RGD:62025
Macaca mulatta	RPS14	VGNC	VGNC:76926
Mus musculus	RPS14	MGD	MGI:98107
Others	RPS14	NCBI