SH3BGR - SH3 domain binding glutamate rich protein Gene

Also Known as 21-GARP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6450

About SH3BGR

Cytogenetic location: 21q22.2 Genomic coordinates (GRCh38): 21:39,445,865-39,515,506 (from NCBI)

This gene has 10 transcripts (splice variants), 190 orthologues and 3 paralogues. Biased expression in heart (RPKM 36.2), prostate (RPKM 11.6) and 10 other tissues.

Summary

Predicted to enable SH3 domain binding activity. Predicted to be involved in protein-containing complex assembly. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

SH3BGR Products (5)

mRNA Protein Name
NM_001001713.1 NP_001001713.1 SH3 domain-binding glutamic acid-rich protein isoform b
NM_001317740.2 NP_001304669.2 SH3 domain-binding glutamic acid-rich protein isoform c
NM_001317741.1 NP_001304670.1 SH3 domain-binding glutamic acid-rich protein isoform d
NM_001317742.1 NP_001304671.1 SH3 domain-binding glutamic acid-rich protein isoform b
NM_007341.3 NP_031367.2 SH3 domain-binding glutamic acid-rich protein isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SH3BGR Protein Structure

SH3BGR

SH3BGR: SH3-binding, glutamic acid-rich protein (64 - 161)

  • 0
  • 100
  • 200
  • 239 a.a.
Protein Preferred Names Protein Names

SH3 domain-binding glutamic acid-rich protein

  • SH3-binding domain and glutamic acid-rich protein

SH3BGR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
SH3BGR P55822 DCP1B Homo sapiens Q8IZD4
Anti Tag CoIP
28514442
Intra
SH3BGR P55822 DCP1B Homo sapiens Q8IZD4
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Down Syndrome

  • Trisomy 21

  • Complete Trisomy 21 Syndrome

  • Down'S Syndrome

  • Trisomy 21 Syndrome

  • Down'S Syndrome - Trisomy 21

  • Downs Syndrome

  • G Trisomy

  • 47,Xx,+21

  • 47,Xy,+21

  • Trisomy G

  • Down Syndrome, Susceptibility To

  • Chromosome 21 Trisomy

  • Trisomy 21 Nos

  • Abnormal Autosomes 21
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS12826 SH3BGR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12827 SH3BGRL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SH3BGR VGNC VGNC:77199
Bos taurus SH3BGR VGNC VGNC:34563
Felis catus SH3BGR VGNC VGNC:102841
Mus musculus SH3BGR MGD MGI:1354740
Rattus norvegicus SH3BGR RGD RGD:1563599
Others SH3BGR NCBI