CCKAR - cholecystokinin A receptor Gene

Also Known as CCK-A; CCK1R; CCKRA; CCK1-R

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 886

About CCKAR

Cytogenetic location: 4p15.2 Genomic coordinates (GRCh38): 4:26,481,396-26,490,484 (from NCBI)

This gene has 1 transcript (splice variant), 202 orthologues and 16 paralogues. Biased expression in gall bladder (RPKM 17.2) and stomach (RPKM 6.8).

Summary

This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide Hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008]

CCKAR Products (1)

mRNA	Protein	Name
NM_000730.3	NP_000721.1	cholecystokinin receptor type A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables cholecystokinin receptor activity	IDA IDA: Inferred from direct assay	8503909	GOA
enables peptide hormone binding	IPI IPI: Inferred from physical interaction	8503909	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in cholecystokinin signaling pathway	IDA IDA: Inferred from direct assay	8503909	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in membrane	IDA IDA: Inferred from direct assay	8503909	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCKAR Protein Structure

CholecysA-Rec_N

7tm_1

0
100
200
300
400
428 a.a.

Protein Preferred Names	Protein Names
cholecystokinin receptor type A	CCK-A receptor CCK-AR cholecystokinin type-A receptor cholecystokinin-1 receptor

Related Diseases

Diseases	Alias
Diabetes Mellitus	Diabetes
Gastroesophageal Reflux	Gastroesophageal Reflux Disease Gerd GER Gastroesophageal Reflux, Pediatric Acid Reflux Gastresophageal Reflux Gastro-Esophageal Reflux Gerd - Gastro-Esophageal Reflux Disease
Exocrine Pancreatic Insufficiency
Panic Disorder	Panic Anxiety Syndrome Panic Panic Disorder 1 Episodic Paroxysmal Anxiety Disorder
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Gastrointestinal System Disease	Gastrointestinal Disease Gastrointestinal Diseases Alimentary System Disease Digestive System Disorder Gastroenteropathy Gastrointestinal Disorder Git Disease Digestive System Diseases Gastrointestinal Disorders Digestive System Disease Digestive System Disorders
Cascade Stomach	Hourglass Stricture Or Stenosis Of Stomach Hourglass Contraction Of Stomach Hourglass Stenosis Of Stomach Hourglass Stricture Of Stomach
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Cholecystitis	Acute Cholecystitis Chronic Cholecystitis Acalculous Cholecystitis Acute And Chronic Cholecystitis Acute On Chronic Cholecystitis Gallstone Cholecystitis Cholecystitis, Acute Calculus Of Gallbladder With Cholecystitis Gallbladder Inflammation Acute Cholecystitis Infection Acute Acalculous Cholecystitis Chronic Acalculous Cholecystitis Nonfunctioning Gallbladder
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Eating Disorder	Eating Disorders Feeding And Eating Disorders
Pancreas Disease	Abnormality Of The Pancreas Pancreatic Diseases
Functionless Pituitary Adenoma	Non-Functioning Neoplasm Of The Pituitary Non-Secretory Adenoma Of The Pituitary Gland Non-Functioning Pituitary Gland Neoplasm
Cholelithiasis
Cholecystolithiasis
Gallbladder Disease	Gallbladder Diseases Gall Bladder Gall Bladder Diseases Abnormal Gallbladder Function

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-128878	Dexloxiglumide	Antagonist	98.25%	Phase 3
HY-101764	Lintitript	Antagonist	99.58%	Phase 2
HY-105257	Pranazepide	Antagonist	99.81%	Phase 2
HY-11077	SR 146131	Agonist	98.23%	Phase 1

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P1096	A71623	Agonist	99.34%	Unkown
HY-B2154	Loxiglumide	Antagonist	98.0%	Unkown
HY-129810	PD 135158	Antagonist	/	Unkown
HY-U00363	CHEMBL333994	Antagonist	/	Unkown
HY-123434	PD-149164	Agonist	/	Unkown
HY-119127	TP-680	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CCKAR	RGD	RGD:2289
Canis familiaris	CCKAR	VGNC	VGNC:38879
Bos taurus	CCKAR	VGNC	VGNC:26941
Mus musculus	CCKAR	MGD	MGI:99478
Felis catus	CCKAR	VGNC	VGNC:60536
Macaca mulatta	CCKAR	VGNC	VGNC:106561
Others	CCKAR	NCBI